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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Feng, Yiping Xu, Qingsheng Wu, Pan |
| Description | Author Affiliation: Xu Q ( From the Department of Neurosurgery, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou Zhejiang Province, People's Republic of China.) |
| Abstract | Hemophilic pseudotumor is a rare but well-known complication of hemophilia manifesting as recurrent hemorrhage and progressive enlargement of hematoma. A patient with severe hemophilia has 1% to 2% chance to develop pseudotumor. The chronic pressure of osseous hemorrhage usually results in bone destruction or resorption. Cranial hemophilic pseudotumors are extremely rare, with only 7 reported cases associated with mild or moderate factor VIII or IX deficiency. A 42-year-old man with a mild factor VIII deficiency developed a pseudotumor of the bilateral skull. Computed tomography and magnetic resonance imaging revealed an extra-axial lesion with bone destruction, and signal changes are consistent with chronic hemorrhage. With adequate factor-deficient replacement therapy, surgical removal was performed. Histologic examination disclosed old blood coagulum. No recurrence was observed in 3 years of follow-up. Cranial hemophilic pseudotumor is extremely rare, and with adequate factor-deficient replacement therapy, surgical management is a safe and effective way for cranial hemophilic pseudotumor treatment. |
| ISSN | 10492275 |
| Issue Number | 4 |
| Volume Number | 25 |
| e-ISSN | 15363732 |
| Journal | Journal of Craniofacial Surgery |
| Language | English |
| Publisher | Lippincott Williams & Wilkins |
| Publisher Date | 2014-07-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Bone Diseases Etiology Hematoma Hemophilia A Complications Occipital Bone Pathology Parietal Bone Adult Surgery Coagulants Therapeutic Use Factor Viii Follow-up Studies Drug Therapy Hemorrhage Humans Magnetic Resonance Imaging Male Osteolysis Pressure Recurrence Tomography, X-ray Computed Case Reports Journal Article Discipline Medicine Discipline Otorhinolaryngology Discipline Surgery |
| Content Type | Text |
| Resource Type | Article Case study |
| Subject | Otorhinolaryngology Surgery |
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