NDLI: Review of histologic and immunohistochemical features of spindle cell carcinomas (carcinosarcomas) of the larynx.

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Review of histologic and immunohistochemical features of spindle cell carcinomas (carcinosarcomas) of the larynx.

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Review of histologic and immunohistochemical features of spindle cell carcinomas (carcinosarcomas) of the larynx.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Bongioannini, Guido Boffano, Paolo De Stefani, Antonella
Description	Country affiliation: Italy Author Affiliation: De Stefani A ( From the *Division of Otorhinolaryngology, Ospedale Umberto I, Turin, Italy.)
Abstract	BACKGROUND: Laryngeal carcinosarcomas pose a significant diagnostic challenge to the pathologist; differential diagnosis needs histochemical and immunohistochemical investigations. MATERIALS AND METHODS: A retrospective review of charts of the pathology database was performed by a search for carcinosarcoma cases. Immunohistochemistry was performed on the representative paraffin blocks in all cases. RESULTS: This study included a total of 5 cases of carcinosarcomas of the larynx. The sarcomatoid component of the tumor was arranged in various patterns mimicking mesenchymal malignancies. Tumor cells were seen arranged in fascicles (a patient), in a storiform (3 patients), or in a solid (a case) pattern. The epithelial markers EMA and AE1/AE3 were positive in all 5 patients, as well as vimentin and CK34betaE12. DISCUSSION: Immunohistochemical studies of epithelial and mesenchymal markers (such as AE1/AE3, epithelial membrane antigens, vimentin, desmin, and S-100) are fundamental to diagnose the tumor, although they may widely vary.
ISSN	10492275
Issue Number	5
Volume Number	25
e-ISSN	15363732
Journal	Journal of Craniofacial Surgery
Language	English
Publisher	Lippincott Williams & Wilkins
Publisher Date	2014-09-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Tumor Markers, Biological Analysis Carcinoma Pathology Carcinosarcoma Laryngeal Neoplasms Aged Aged, 80 And Over Humans Immunohistochemistry Larynx Male Middle Aged Retrospective Studies Journal Article Discipline Medicine Discipline Otorhinolaryngology Discipline Surgery
Content Type	Text
Resource Type	Article
Subject	Otorhinolaryngology Surgery

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