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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Cama, Giuseppe Edirisinghe, Mohan Labbaf, Sheyda Stride, Eleanor Deb, Sanjukta |
| Description | Author Affiliation: Labbaf S ( Department of Mechanical Engineering, Biomaterials Research Laboratory, University College London, Torrington Place, London WC1 7JE, UK. Electronic address: s.labbaf@ucl.ac.uk.) |
| Abstract | Control over the size and morphology of polymeric carriers for drug delivery systems is essential to optimize their functionality. In the current study, we demonstrate the feasibility of using an electrohydrodynamic process with a triple-needle device to prepare nearly mono-dispersed, spherical, tri-layered sub-micron particles. Three biocompatible polymer solutions of poly (lactic-co-glycolic acid) (PLGA), polycaprolactone (PCL) and polymethylsilsesquioxane (PMSQ) were used to prepare particles with three distinct layers. Optimized particles were shown to be spherical with an average size ranging from 320 nm (±80 nm) to 220 (±8 nm), which varied with a change in the working distance in the electrohydrodynamic processing. The surface and internal structure and morphology were studied using confocal, transmission and scanning electron microscopy combined with focused ion beam sectioning. Cytotoxicity was shown to be negligible in an in vitro assay. The ability to fabricate such multilayered particles in a single step, under ambient conditions has considerable potential for a range of applications in particular controlled release drug delivery system. |
| ISSN | 00219797 |
| Volume Number | 409 |
| e-ISSN | 10957103 |
| Journal | Journal of Colloid and Interface Science |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-11-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Biocompatible Materials Chemical Synthesis Electrochemical Techniques Hydrodynamics Polymers Chemistry Cell Survival Cells, Cultured Drug Carriers Drug Delivery Systems Instrumentation Humans Microscopy, Fluorescence Osteoblasts Cytology Metabolism Particle Size Structure-activity Relationship Surface Properties Journal Article Research Support, Non-u.s. Gov't Discipline Colloid & Interface Science |
| Content Type | Text |
| Resource Type | Article |
| Subject | Surfaces, Coatings and Films Colloid and Surface Chemistry Biomaterials Electronic, Optical and Magnetic Materials |
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