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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Wang, Yinsong Feng, Fuli Yang, Xiaoying Yang, Xinlin Li, Rongrong Yang, Victor C. |
| Description | Author Affiliation: Li R ( Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), Basic Medical Research Center, School of Pharmacy, Tianjin Medical University, Tianjin 300070, PR China.); Feng F ( Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), Basic Medical Research Center, School of Pharmacy, Tianjin Medical University, Tianjin 300070, PR China.); Wang Y ( Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), Basic Medical Research Center, School of Pharmacy, Tianjin Medical University, Tianjin 300070, PR China.); Yang X ( Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), Basic Medical Research Center, School of Pharmacy, Tianjin Medical University, Tianjin 300070, PR China. Electronic address: yangxiaoying@tijmu.edu.cn.); Yang X ( Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, PR China. Electronic address: xlyang88@nankai.edu.cn.); Yang VC ( Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), Basic Medical Research Center, School of Pharmacy, Tianjin Medical University, Tianjin 300070, PR China.) |
| Abstract | The folic acid (FA)-conjugated pH/temperature/redox multi-stimuli responsive poly(methacrylic acid-co-N,N-bis(acryloyl)cystamine/poly(N-isopropylacrylamide-co-glycidyl methacrylate-co-N,N-bis(acryloyl)cystamine) microspheres were prepared by a two-stage distillation-precipitation polymerization with subsequent surface modification with FA. The microspheres were characterized by transmission electron microscopy, dynamical light scattering, Fourier-transform infrared spectra, UV-vis spectra and elemental analysis. The degradation of the functional microspheres could be triggered by a reductive reagent, such as glutathione, due to presence of BAC crosslinker. The drug-loaded microspheres exhibited a pH/temperature/redox multi-stimuli responsive drug release character for doxorubicin hydrochloride as a model anti-cancer drug, which was efficiently loaded into the microspheres with a high loading capacity of 208.0% and an encapsulation efficiency of 85.4%. In vitro drug delivery study indicated that the FA-conjugated microspheres could deliver Dox into MCF-7 cells more efficiently than the microspheres without functionalization of FA. Furthermore, WST-1 assay showed that the microspheres had no obvious toxicity to MCF-7 cells even at a high concentration of 2000 µg mL(-1). The resultant microsphere may be a promising vector for delivery of anti-cancer drugs as it exhibits a low cytotoxicity and degradability, precise molecular targeting property and multi-stimuli responsively controlled drug release. |
| ISSN | 00219797 |
| Volume Number | 429 |
| e-ISSN | 10957103 |
| Journal | Journal of Colloid and Interface Science |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2014-09-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Antineoplastic Agents Administration & Dosage Folic Acid Chemistry Microspheres Polymers Drug Carriers Hydrogen-ion Concentration Microscopy, Electron, Transmission Oxidation-reduction Spectroscopy, Fourier Transform Infrared Temperature Journal Article Research Support, Non-u.s. Gov't Discipline Colloid & Interface Science |
| Content Type | Text |
| Resource Type | Article |
| Subject | Surfaces, Coatings and Films Colloid and Surface Chemistry Biomaterials Electronic, Optical and Magnetic Materials |
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