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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Tian, Kai Luo, Yuan Jiang, Long Quan, Dongqin Li, Wanhua Wang, Yongan Rong, Huilin Li, Xiaoqin Wang, Haifei |
| Description | Author Affiliation: Li X ( Beijing National Laboratory for Molecular Sciences, Key Laboratory of Colloids and Interface Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, People's Republic of China.); Wang H ( Beijing National Laboratory for Molecular Sciences, Key Laboratory of Colloids and Interface Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, People's Republic of China.); Rong H ( Beijing National Laboratory for Molecular Sciences, Key Laboratory of Colloids and Interface Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, People's Republic of China.); Li W ( Institutes of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, People's Republic of China.); Luo Y ( Institutes of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, People's Republic of China.); Tian K ( Institutes of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, People's Republic of China.); Quan D ( Institutes of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, People's Republic of China.); Wang Y ( Institutes of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, People's Republic of China. Electronic address: yonganw@sina.com.); Jiang L ( Beijing National Laboratory for Molecular Sciences, Key Laboratory of Colloids and Interface Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, People's Republic of China. Electronic address: jiangl@iccas.ac.cn.) |
| Abstract | Recently gold nanomaterials have been widely applied in the biomedical field, but their biosafety is still controversial. We immobilized small gold nanoparticles (AuNPs) on a large silica substrate to form silica-gold core-shell materials (SiO2@AuNPs) via classical seed-mediated growth. In vitro, 500 nm-SiO2@AuNPs could promote the proliferation of mouse embryonic fibroblast cells (NIH/3T3). The results of transmission electron microscope (TEM) showed that the vast majority of particles did not enter cells and that the morphology of microtubules experienced no change as observed in the confocal microscope images. The mechanism may be that the large silica substrate kept AuNPs outside the cells and the nano-size concavo-convex gold shell facilitated to cell adhesion, resulting in the proliferation. In vivo, a cutaneous full-thickness excisional wound rat model was applied to assess the healing efficiency of 500 nm-SiO2@AuNPs. The results indicated that SiO2@AuNPs could promote wound healing, which was potentially related to the anti-inflammatory and antioxidation of AuNPs. The pathological finding showed that the healing levels of SiO2@AuNPs were significantly better than those of the control groups. Our study may provide insight into the application of silica-gold core-shell materials in the treatment of cutaneous wounds. |
| ISSN | 00219797 |
| Volume Number | 445 |
| e-ISSN | 10957103 |
| Journal | Journal of Colloid and Interface Science |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-05-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Anti-inflammatory Agents Therapeutic Use Antioxidants Gold Metal Nanoparticles Silicon Dioxide Wound Healing Drug Effects Animals Cell Proliferation Male Mice Nih 3t3 Cells Rats Rats, Sprague-dawley Journal Article Research Support, Non-u.s. Gov't Discipline Colloid & Interface Science |
| Content Type | Text |
| Resource Type | Article |
| Subject | Surfaces, Coatings and Films Colloid and Surface Chemistry Biomaterials Electronic, Optical and Magnetic Materials |
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