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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Yang, Bo Khan, Faez Iqbal Xin, Ruipu Zhao, Zexin Wang, Yonghua Zhang, Zedong |
| Description | Author Affiliation: Xin R ( College of Food Sciences and Engineering, South China University of Technology, Guangzhou 510640, PR China.); Khan FI ( School of Chemistry and Chemical Engineering, Henan University of Technology, Zhengzhou 450001, PR China.); Zhao Z ( School of Bioscience and Bioengineering, South China University of Technology, Guangzhou 510006, PR China.); Zhang Z ( College of Food Sciences and Engineering, South China University of Technology, Guangzhou 510640, PR China.); Yang B ( School of Bioscience and Bioengineering, South China University of Technology, Guangzhou 510006, PR China.); Wang Y ( College of Food Sciences and Engineering, South China University of Technology, Guangzhou 510640, PR China. Electronic address: yonghw@scut.edu.cn.) |
| Abstract | The mechanism of lipase binding to the lipid-water interface is crucial for substrate specificity and kinetic properties. In this study, the chain-length specificity, regiospecificity and substrate specificity of Phospholipase A (PLA ) and its parent enzyme Thermomyces lanuginosus lipase (TLL) have been investigated using a classical emulsion system. The results show that both PLA and TLL are 1,3-regioselective lipases. Additionally, the hydrolytic activity of PLA is comparatively lower on short-chain triacylglyceride (TAG) and higher on phosphatidylcholine (PC) than the hydrolytic activity of TLL. Further, the results obtained with monolayer film techniques demonstrate that the C-terminal region regulates the binding of PLA to PC. A hypothesis is presented according to which the 9 helix of C-terminal region in PLA not only controls the opening of lid but also serves as a membrane anchor that assists in binding to PC. These findings bring new insight into rational design of novel lipases with intriguing functionalities. |
| ISSN | 00219797 |
| Journal | Journal of Colloid and Interface Science |
| Volume Number | 488 |
| e-ISSN | 10957103 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2017-02-15 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Colloid & Interface Science |
| Content Type | Text |
| Resource Type | Article |
| Subject | Surfaces, Coatings and Films Colloid and Surface Chemistry Biomaterials Electronic, Optical and Magnetic Materials |
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