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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ferreira, F. Massaldi, H. Franco Fraguas, L. Suárez, N. |
| Description | Country affiliation: Uruguay Author Affiliation: Suárez N ( Laboratorio de Carbohidratos y Glicoconjugados, Departamento de Desarrollo Biotecnológico y División Producción, Facultades de Medicina/Química, Instituto de, Higiene, Av. Alfredo Navarro 3051, CP 11600, Montevideo, Uruguay.) |
| Abstract | A glycoconjugate constituted by the Streptococcus pneumoniae serotype 14 capsular polysaccharide (CPS14) and bovine serum albumin (BSA) was prepared, and the unique properties of Sephadex LH-20 were used to separate the conjugate from the unconjugated material. The strength of this approach consists in its capacity to produce pure polysaccharide-protein conjugate in good yield and free from unconjugated material, a common residual contaminant of this type of immunobiologicals. The CPS14-BSA conjugate prepared via an improved 1-cyano-4-dimethylaminopyridinium tetrafluoroborate (CDAP)-activation technique was characterized chemically and its immunogenicity was evaluated in mice. The purified conjugate, unlike the corresponding polysaccharide, produced a T-cell-dependent response in this species. |
| ISSN | 00219673 |
| Issue Number | 2 |
| Volume Number | 1213 |
| e-ISSN | 18733778 |
| Journal | Journal of Chromatography A |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2008-12-12 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Bacterial Capsules Immunology Isolation & Purification Bacterial Vaccines Glycoconjugates Chemical Synthesis Streptococcus Pneumoniae Animals Female Mice Serum Albumin, Bovine Journal Article Research Support, Non-u.s. Gov't Discipline Analytical Chemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Medicine Analytical Chemistry Biochemistry |
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