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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Gargano, Andrea F. G. Lindner, Wolfgang Lämmerhofer, Michael |
| Description | Country affiliation: Austria Author Affiliation: Gargano AF ( Department of Analytical Chemistry, University of Vienna, Waehringer Strasse 38, 1090 Vienna, Austria.) |
| Abstract | In the present contribution we report a HPLC enantioseparation method for a library of amido-aminophosphonate structures generated by a novel Ugi-multicomponent reaction. The enantioseparation of these novel potentially bioactive molecules was achieved by means of HPLC on cinchona-carbamate based chiral anion-exchangers under polar organic elution conditions. The compounds were synthesized with the aim of offering a wide degree of heterogeneity in terms of structural elements to evaluate the influence of various structural motifs on enantioselectivity. The resultant compound library allows to derive structure-enantioselectivity relationships useful for understanding the chiral recognition process. As part of the study mobile phase characteristics such as concentration and type of counterion, mobile phase composition, apparent pH and temperature were investigated with regards to their effect on the separation performances. Employing a single mass spectrometry-compatible mobile phase, 23 compounds out of a pool of 42 racemic amido-aminophosphonate structures reached full baseline separation (Rs>1.5) and 5 were almost baseline separated (1 |
| ISSN | 00219673 |
| Volume Number | 1310 |
| e-ISSN | 18733778 |
| Journal | Journal of Chromatography A |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-10-04 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Carbamates Chemistry Chromatography, High Pressure Liquid Instrumentation Methods Phosphopeptides Acetonitriles Aldehydes Methanol Models, Chemical Isolation & Purification Phosphorous Acids Small Molecule Libraries Stereoisomerism Temperature Thermodynamics Journal Article Research Support, Non-u.s. Gov't Discipline Analytical Chemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Medicine Analytical Chemistry Biochemistry |
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