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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ruiz-Angel, M. J. Ubeda-Torres, M. T. García-Alvarez-Coque, M. C. Ortiz-Bolsico, C. |
| Description | Country affiliation: Spain Author Affiliation: Ubeda-Torres MT ( Departament de Química Analítica, Universitat de València, c/Dr. Moliner 50, Burjassot, Spain.); Ortiz-Bolsico C ( Departament de Química Analítica, Universitat de València, c/Dr. Moliner 50, Burjassot, Spain.); García-Alvarez-Coque MC ( Departament de Química Analítica, Universitat de València, c/Dr. Moliner 50, Burjassot, Spain.); Ruiz-Angel MJ ( Departament de Química Analítica, Universitat de València, c/Dr. Moliner 50, Burjassot, Spain. Electronic address: mjruiz@uv.es.) |
| Abstract | In reversed-phase liquid chromatography in the absence of additives, cationic basic compounds give rise to broad and asymmetrical peaks as a result of ionic interactions with residual free silanols on silica-based stationary phases. Ionic liquids (ILs), added to the mobile phase, have been suggested as alternatives to amines to block the activity of silanols. However, the dual character of ILs should be considered: both cation and anion may be adsorbed on the stationary phase, thereby creating a double asymmetrical layer positively or negatively charged, depending on the relative adsorption of both ions. In this work, a study of the performance of six imidazolium-based ILs (the chlorides and tetrafluoroborates of 1-ethyl-, 1-butyl- and 1-hexyl-3-methylimidazolium) as modifiers of the chromatographic behaviour of a group of 10 ß-blockers is performed, and compared with triethylamine and dimethyloctylamine. In order to gain more insight in the behaviour of ILs in RPLC, the changes in the nature of the chromatographic system, at increasing concentration of the additives, were followed based on retention and peak shape modelling. The multiple interactions that amines and ILs experience inside the chromatographic system suggest that the suppressing potency should be measured based on the shape of chromatographic peaks and not on the changes in retention. The ILs 1-hexyl-3-methyl-imidazolium chloride and tetrafluoroborate offered the most interesting features for the separation of the basic drugs. |
| ISSN | 00219673 |
| Volume Number | 1380 |
| e-ISSN | 18733778 |
| Journal | Journal of Chromatography A |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-02-06 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Chromatography, High Pressure Liquid Methods Chromatography, Reverse-phase Imidazoles Chemistry Ionic Liquids Adrenergic Beta-1 Receptor Antagonists Isolation & Purification Amines Borates Chlorides Journal Article Research Support, Non-u.s. Gov't Discipline Analytical Chemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Medicine Analytical Chemistry Biochemistry |
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