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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Liu, Wan-Ling Yang, Yicong Wu, Lin-Tai Lirio, Stephen Hsiao, Shu-Ying Huang, Hsi-Ya |
| Description | Country affiliation: Taiwan Author Affiliation: Liu WL ( Department of Chemistry, Chung Yuan Christian University, 200 Chung Pei Road, Chung-Li 320, Taiwan.); Lirio S ( Department of Chemistry, Chung Yuan Christian University, 200 Chung Pei Road, Chung-Li 320, Taiwan.); Yang Y ( Department of Chemistry, Chung Yuan Christian University, 200 Chung Pei Road, Chung-Li 320, Taiwan); Wu LT ( Department of Chemistry, Chung Yuan Christian University, 200 Chung Pei Road, Chung-Li 320, Taiwan.); Hsiao SY ( Department of Chemistry, Chung Yuan Christian University, 200 Chung Pei Road, Chung-Li 320, Taiwan.); Huang HY ( Department of Chemistry, Chung Yuan Christian University, 200 Chung Pei Road, Chung-Li 320, Taiwan. Electronic address: hyhuang@cycu.edu.tw.) |
| Abstract | In this study, an organic polymer monolithic columns, which were prepared via in situ polymerization of alkyl methacrylate-ester (AMA), divinylbenzene (DVB) and vinylbenzyl trimethylammonium chloride (VBTA, charged monomer), were developed as adsorbent for solid-phase microextraction (SPME). Different parameters affecting the extraction efficiency for nine (9) non-steroidal anti-inflammatory drugs (NSAIDs) such as the ratio of the stearyl methacrylate (SMA) to DVB monomer, column length, sample pH, extraction flow rate and desorption solvent were investigated to obtain the optimal SPME condition. Also, the permeability for each poly(AMA-DVB-VBTA) monolithic column was investigated by adding porogenic solvent (poly(ethylene glycol), PEG). Using the optimized condition, a series of AMA-based poly(AMA-DVB-VBTA) monolith columns were developed to determine the effect the extraction efficiency of NSAIDs by varying the alkyl chain length of the methacrylate ester (methyl-, butyl-, octyl-, or lauryl-methacrylate; (MMA, BMA, OMA, LMA)). Results showed that decreasing the AMA chain length increases the extraction efficiency of some NSAIDs (i.e. sulindac (sul), naproxen (nap), ketoprofen (ket) and indomethacin (idm)). Among the poly(AMA-DVB-VBTA) monolithic columns, poly(BMA-DVB-VBTA) showed a highly repeatable extraction efficiency for NSAIDs with recoveries ranging from 85.0 to 100.2% with relative standard deviation (RSD) less than 6.8% (n=3). The poly(BMA-DVB-VBTA) can also be reused for at least 50 times without any significant effect in extraction efficiency for NSAIDs. Finally, using the established conditions, the poly(BMA-DVB-VBTA) was used to extract trace-level NSAIDs (100µgL(-1)) in river water with good recoveries ranging from 75.8 to 90.8% (RSD<14.9%). |
| ISSN | 00219673 |
| Volume Number | 1395 |
| e-ISSN | 18733778 |
| Journal | Journal of Chromatography A |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-05-22 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Solid Phase Microextraction Instrumentation Anti-inflammatory Agents, Non-steroidal Isolation & Purification Methacrylates Chemistry Polymerization Reproducibility Of Results Vinyl Compounds Journal Article Research Support, Non-u.s. Gov't Discipline Analytical Chemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Medicine Analytical Chemistry Biochemistry |
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