NDLI: Purification of organic acids by chromatography with strong anionic resins: Investigation of uptake mechanisms.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lemaire, Julien Lutin, Florence Blanc, Claire-Line Théoleyre, Marc-André Stambouli, Moncef Pareau, Dominique
Description	Author Affiliation: Lemaire J ( LGPM, CentraleSupélec, Université Paris-Saclay, SFR Condorcet FR CNRS 3417, Centre Européen de Biotechnologie et de Bioéconomie (CEBB), 3 rue des Rouges-Terres, 51110 Pomacle, France. Electronic address: julien.lemaire@centralesupelec.fr.); Blanc CL ( LGPM, CentraleSupélec, Université Paris-Saclay, SFR Condorcet FR CNRS 3417, Centre Européen de Biotechnologie et de Bioéconomie (CEBB), 3 rue des Rouges-Terres, 51110 Pomacle, France); Lutin F ( Eurodia Industrie, ZAC Saint Martin, Impasse Saint Martin, 84120 Pertuis, France.); Théoleyre MA ( LGPM, CentraleSupélec, Université Paris-Saclay, SFR Condorcet FR CNRS 3417, Centre Européen de Biotechnologie et de Bioéconomie (CEBB), 3 rue des Rouges-Terres, 51110 Pomacle, France.); Stambouli M ( LGPM, CentraleSupélec, Université Paris-Saclay, SFR Condorcet FR CNRS 3417, Centre Européen de Biotechnologie et de Bioéconomie (CEBB), 3 rue des Rouges-Terres, 51110 Pomacle, France.); Pareau D ( LGPM, CentraleSupélec, Université Paris-Saclay, SFR Condorcet FR CNRS 3417, Centre Européen de Biotechnologie et de Bioéconomie (CEBB), 3 rue des Rouges-Terres, 51110 Pomacle, France.)
Abstract	Bio-based organic acids are promising renewable carbon sources for the chemical industry. However energy-consuming purification processes are used, like distillation or crystallization, to reach high purities required in some applications. That is why preparative chromatography was studied as an alternative separation technique. In a previous work dealing with the purification of lactic, succinic and citric acids, the Langmuir model was insufficient to explain the elution profiles obtained with a strong anionic resin. Consequently the Langmuir model was coupled with a usual ion-exchange model to take into account the retention of their conjugate bases (<2%), which are commonly neglected at low pH (<1.5). Elution simulations with both uptake mechanisms fitted very well with experimental pulse tests. Only two parameters were optimized (equilibrium constant of acid uptake and ion-exchange selectivity coefficient of conjugate base) and their value were coherent with experimental and resin suppliers' data. These results confirmed that the singular tailing and apparent delay observed with succinic and citric acids can be explained by the high affinity of succinate and citrate for resin cationic sites. The model was implemented in a preparative chromatography simulation program in order to optimize operating parameters of our pilot-scale ISMB unit (Improved Simulated Moving Bed). The comparison with experimental ISMB profiles was conclusive.
ISSN	00219673
Journal	Journal of Chromatography A
Volume Number	1458
e-ISSN	18733778
Language	English
Publisher	Elsevier
Publisher Date	2016-08-05
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Analytical Chemistry
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Medicine Analytical Chemistry Biochemistry

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