NDLI: Normal pregnancy- a state of insulin resistance.

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Normal pregnancy- a state of insulin resistance.

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Normal pregnancy- a state of insulin resistance.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Biradar, Shivaleela M. Murthy D. S., Jayaprakash Dattatreya, K. Sonagra, Amit D.
Description	Country affiliation: India Author Affiliation: Sonagra AD ( Assistant Professor, Department of Biochemistry, GMERS Medical College , Dharpur-Patan, Gujarat, India .); Biradar SM ( Assistant Professor, Department of Biochemistry, BLDEA's Shri BM Patil Medical College , Bijapur, Karnataka, India .); K D ( Professor, Department of Biochemistry, JJM Medical College , Davangere, Karnataka, India .); Murthy D S J ( Professor & Head, Department of Biochemistry, The Oxford Medical College, Hospital & Research Centre , Bangalore, Karnataka, India .)
Abstract	BACKGROUND: Purpose of insulin resistance (IR) adapted by mother is to deliver enough quantity of nutrients to the growing fetus. Many maternal hormones and factors play role in causation of IR during pregnancy. AIM: The study aims at evaluating IR at different trimesters of pregnancy. MATERIALS AND METHODS: Pregnant women at 1(st), 2(nd) and 3(rd) trimester were grouped into groups I, II and III respectively (n=20 in each group). Healthy non-pregnant women were taken as controls (n=30). Fasting plasma glucose (FPG) and fasting serum insulin (FSI) were measured and IR indices such as fasting glucose to insulin ratio (FGIR), quantitative insulin sensitivity check index (QUICKI), log FSI and log HOMA1-IR were calculated. The student's t-test and one way Analysis of variance (ANOVA) were used for data analysis. RESULTS: The mean FSI, log FSI and log HOMA 1-IR were significantly higher in 2(nd) and 3(rd) trimesters while QUICKI was significantly lower in 2(nd) and 3(rd) trimesters of pregnancy when compared with controls. Also, mean FGIR was found to be significantly lower in 3rd trimester when compared with controls. CONCLUSION: As pregnancy advances, IR increases. Increased IR is associated with poor maternal and fetal outcome. Screening of all pregnancy for IR and early intervention may help to reduce the associated complications.
ISSN	2249782X
e-ISSN	0973709X
DOI	10.7860/JCDR/2014/10068.5081
Journal	JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH
Issue Number	11
Volume Number	8
Language	English
Publisher	Dr. Hemant Jain (for Premchand Shantidevi Research Foundation)
Publisher Date	2014-11-01
Publisher Place	India
Access Restriction	Open
Subject Keyword	Discipline Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Clinical Biochemistry

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