NDLI: Induction and mechanism of apoptosis by hydroxycamptothecin in human Tenon's capsule fibroblasts.

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Induction and mechanism of apoptosis by hydroxycamptothecin in human Tenon's capsule fibroblasts.

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Induction and mechanism of apoptosis by hydroxycamptothecin in human Tenon's capsule fibroblasts.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zhang, Yujie Tang, Wei Qian, Chaoxu Du, Jun Yuan, Zhilan
Description	Country affiliation: China Author Affiliation: Tang W ( Department of Ophthalmology, the First Affiliated Hospital of Nanjing Medical University, Jiangsu Province, China.)
Abstract	PURPOSE: We investigated apoptosis induced by hydroxycamptothecin (HCPT) in human Tenon's capsule using fibroblasts cultured from human Tenon's capsule (HTFs), and the mechanism of induction. METHODS: HTFs were treated with 0-4 mg/L HCPT for 24 hours. Cell proliferation was measured by 3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide (MTT) assay, and apoptotic cells were analyzed by Hoechst 33258 stain. The mRNA and protein levels of caspase-3, -8, and -9 were detected by RT-PCR and Western blotting. RESULTS: By MTT assay, HCPT induced apoptosis in HTFs in a concentration- and time-dependent manner. Hoechst 33258 staining and transmission electron microscopy showed typical apoptotic morphology, such as condensed chromatin, irregular nuclei, and apoptotic body formation. The mRNA and protein levels of caspase-3 and caspase-9 were upregulated, while caspase-8 was unchanged. Z-VAD-FMK, a caspase inhibitor, inhibited the apoptosis of fibroblasts induced by HCPT. The expression levels of caspase-3 and caspase-9 were down-regulated after Z-VAD-FMK treatment. CONCLUSIONS: Caspase-3 and caspase-9 are important elements in regulating HCPT-induced apoptosis in HTFs.
ISSN	01460404
e-ISSN	15525783
Journal	Investigative Opthalmology & Visual Science
Issue Number	8
Volume Number	53
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2012-07-24
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antineoplastic Agents, Phytogenic Pharmacology Apoptosis Physiology Camptothecin Analogs & Derivatives Caspase 3 Metabolism Caspase 8 Caspase 9 Fibroblasts Tenon Capsule Amino Acid Chloromethyl Ketones Drug Effects Blotting, Western Cysteine Proteinase Inhibitors Microscopy, Electron, Transmission Rna, Messenger Reverse Transcriptase Polymerase Chain Reaction Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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