NDLI: Transforming growth factor-ß2 induces expression of biologically active bone morphogenetic protein-1 in human trabecular meshwork cells.

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Transforming growth factor-ß2 induces expression of biologically active bone morphogenetic protein-1 in human trabecular meshwork cells.

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Transforming growth factor-ß2 induces expression of biologically active bone morphogenetic protein-1 in human trabecular meshwork cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wordinger, Robert J. Tovar-Vidales, Tara Clark, Abbot F. Fitzgerald, Ashley M.
Description	Country affiliation: United States Author Affiliation: Tovar-Vidales T ( Department of Cell Biology and Anatomy, and the North Texas Eye Research Institute, University of North Texas Health Science Center at Fort Worth, Fort Worth, Texas 76107, USA. tara.tovar-vidales@unthsc.edu)
Abstract	PURPOSE: There are limited studies on the factors that regulate the processing of TGF-ß2 and extracellular matrix (ECM) proteins into their mature form. Bone morphogenic protein 1 (BMP1) is an enzyme responsible for the cleavage and maturation of growth factors and ECM proteins. The purpose of our study was to determine whether cultured human trabecular meshwork (TM) cells express BMP1, BMP1 expression is regulated by TGF-ß2, BMP1 is biologically active, and BMP1 regulates LOX activity. METHODS: Primary human TM cells were isolated and subjected to quantitative PCR (qPCR) and Western immunoblotting (WB) for BMP1. BMP1 immunolocalization was performed in TM tissues. qPCR was used to determine BMP1 mRNA expression and WB results were used to determine BMP1 protein expression. BMP1 activity was measured in TM cells treated with TGF-ß2 or with a combination of TGF-ß2/UK383367. Lysyl oxidase (LOX) enzyme activity was evaluated by WB in TM cells treated with BMP1 or with a combination of BMP1/ß-aminoprorionitrile (BAPN). RESULTS: Human TM cells expressed mRNA and protein for BMP1. Exogenous TGF-ß2 increased mRNA expression compared to their controls (P<0.05). An ELISA showed TGF-ß2-induced BMP1 secretion compared to their controls in all cell strains (P<0.05). Secreted BMP1 stimulated LOX enzymatic activity in TM cells. CONCLUSIONS: BMP1 is expressed in the human TM. TGF-ß2 induction of BMP1 may be responsible for increased processing of growth factors and ECM proteins into their mature forms, resulting in TM stiffness and resistance to ECM degradation.
ISSN	01460404
e-ISSN	15525783
DOI	10.1167/iovs.13-12203
Journal	Investigative Opthalmology & Visual Science
Issue Number	7
Volume Number	54
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2013-07-16
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Bone Morphogenetic Protein 1 Metabolism Trabecular Meshwork Drug Effects Transforming Growth Factor Beta2 Pharmacology Blotting, Western Genetics Cells, Cultured Enzyme-linked Immunosorbent Assay Immunohistochemistry Protein-lysine 6-oxidase Rna, Messenger Physiology Research Support, N.i.h., Extramural Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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