NDLI: Characterization of Retinal Disease Progression in a 1-Year Longitudinal Study of Eyes With Mild Nonproliferative Retinopathy in Diabetes Type 2.

Please wait, while we are loading the content...

Year: 2017 Volume: 58

Year: 2016 Volume: 57

Year: 2015 Volume: 56

Year: 2015 Volume: 56 Issue: 13

Year: 2015 Volume: 56 Issue: 12

Year: 2015 Volume: 56 Issue: 11

Year: 2015 Volume: 56 Issue: 10

Year: 2015 Volume: 56 Issue: 9

Evidence for the Involvement of MMP14 in MMP2 Processing and Recruitment in Exosomes of Corneal Fibroblasts.

Baseline Predictors for Good Versus Poor Visual Outcomes in the Treatment of Neovascular Age-Related Macular Degeneration With Intravitreal Anti-VEGF Therapy.

Quantitative Noninvasive Angiography of the Fovea Centralis Using Speckle Variance Optical Coherence Tomography.

Accurate Imputation-Based Screening of Gln368Ter Myocilin Variant in Primary Open-Angle Glaucoma.

4-Acetoxyphenol Prevents RPE Oxidative Stress-Induced Necrosis by Functioning as an NRF2 Stabilizer.

In Vivo Confocal Microscopy of Corneal Nerves: An Ocular Biomarker for Peripheral and Cardiac Autonomic Neuropathy in Type 1 Diabetes Mellitus.

Corneal Confocal Microscopy and Diabetic Neuropathy.

Astigmatism of the Ex Vivo Human Lens: Surface and Gradient Refractive Index Age-Dependent Contributions.

Visual Processing in Infantile Nystagmus Is Not Slow.

Focused Tortuosity Definitions Based on Expert Clinical Assessment of Corneal Subbasal Nerves.

Primary Mechanisms of Thymosin ß4 Repair Activity in Dry Eye Disorders and Other Tissue Injuries.

Ten-Year Incidence of Retinal Nerve Fiber Layer Defects: The Beijing Eye Study 2001/2011.

CaV3.1 T-Type Ca2+ Channels Contribute to Myogenic Signaling in Rat Retinal Arterioles.

Epigenetic Modification of Mitochondrial DNA in the Development of Diabetic Retinopathy.

The Structural Properties of Major White Matter Tracts in Strabismic Amblyopia.

Amblyopia Reveals the Neuroanatomical Consequences of Prolonged Abnormal Binocular Experience.

Molecular Characterization of FZD4, LRP5, and TSPAN12 in Familial Exudative Vitreoretinopathy.

Regulation of ADAM10 and ADAM17 by Sorafenib Inhibits Epithelial-to-Mesenchymal Transition in Epstein-Barr Virus-Infected Retinal Pigment Epithelial Cells.

Erratum. Latanoprost Stimulates Secretion of Matrix Metalloproteinases in Tenon Fibroblasts Both In Vitro and In Vivo.

Topical TSG-6 Administration Protects the Ocular Surface in Two Mouse Models of Inflammation-Related Dry Eye.

Visual Impairments Following Term Neonatal Encephalopathy: Do Retinal Impairments Also Play a Role?

Roles of Epithelial Cell-Derived Type 2-Initiating Cytokines in Experimental Allergic Conjunctivitis.

Histopathological Evaluation of a Hydrophobic Terpolymer (PTFE-PVD-PP) as an Implant Material for Nonpenetrating Very Deep Sclerectomy.

Slit2 Promotes Angiogenic Activity Via the Robo1-VEGFR2-ERK1/2 Pathway in Both In Vivo and In Vitro Studies.

Role of Matrix Metalloproteinases 2 and 9 in Lacrimal Gland Disease in Animal Models of Sjögren's Syndrome.

OCT Angiography Compared to Fluorescein and Indocyanine Green Angiography in Chronic Central Serous Chorioretinopathy.

Polarization-Sensitive Optical Coherence Tomography and Conventional Retinal Imaging Strategies in Assessing Foveal Integrity in Geographic Atrophy.

Identification and Functional Characterization of a GSH Conjugate Efflux Pathway in the Rat Lens.

Total Corneal Astigmatism Measurement.

The Relationship Between Helicobacter pylori Infection and Open-Angle Glaucoma: A Meta-Analysis.

Relationship Between Nocturnal Intraocular Pressure Elevation and Diurnal Intraocular Pressure Level in Normal-Tension Glaucoma Patients.

The Role of LOX and LOXL2 in the Pathogenesis of an Experimental Model of Choroidal Neovascularization.

Multivariate Model of the Intersubject Variability of the Retinal Nerve Fiber Layer Thickness in Healthy Subjects.

Characterization of an Early-Onset, Autosomal Recessive, Progressive Retinal Degeneration in Bengal Cats.

Lens Position and Age: The Central India Eye and Medical Study.

Alteration of N-Glycan Profiles in Diabetic Retinopathy.

Small Fiber Neuropathy and Wilson Disease.

Author Response: Small Fiber Neuropathy and Wilson Disease.

Measurement of Ex Vivo Porcine Lens Shape During Simulated Accommodation, Before and After fs-Laser Treatment.

CD1 Mouse Retina Is Shielded From Iron Overload Caused by a High Iron Diet.

The Contribution of Genetic Architecture to the 10-Year Incidence of Age-Related Macular Degeneration in the Fellow Eye.

Mechanisms of Vertical Fusional Vergence in Patients With 'Congenital Superior Oblique Paresis' Investigated With an Eye-Tracking Haploscope.

Convergence and Accommodation Development Is Preprogrammed in Premature Infants.

Design and Pharmacokinetic Characterization of Novel Antibody Formats for Ocular Therapeutics.

Exposure to Atomic Bomb Radiation and Age-Related Macular Degeneration in Later Life: The Hiroshima-Nagasaki Atomic Bomb Survivor Study.

VEGF Receptor-2–Linked PI3K/Calpain/SIRT1 Activation Mediates Retinal Arteriolar Dilations to VEGF and Shear Stress

Visual Cone Arrestin 4 Contributes to Visual Function and Cone Health.

Imaging of the Corneal Subbasal Whorl-like Nerve Plexus: More Accurate Depiction of the Extent of Corneal Nerve Damage in Patients With Diabetes.

IL-18 Immunotherapy for Neovascular AMD: Tolerability and Efficacy in Nonhuman Primates.

Enhancing Inflammation as an Adjuvant to Neovascular AMD Therapy.

Optical Density of Subretinal Fluid in Retinal Detachment.

Characterization of a New Epitope of IRBP That Induces Moderate to Severe Uveoretinitis in Mice With H-2b Haplotype.

MMP14 Cleavage of VEGFR1 in the Cornea Leads to a VEGF-Trap Antiangiogenic Effect.

Platelet-Derived Growth Factor-BB Enhances Adipogenesis in Orbital Fibroblasts.

Evaluation of Chitosan/Aptamer Targeting TGF-ß Receptor II Thermo-Sensitive Gel for Scarring in Rat Glaucoma Filtration Surgery.

Comparison of Longitudinal Changes in Functional and Structural Measures for Evaluating Progression of Glaucomatous Optic Neuropathy.

Gremlin Induces Ocular Hypertension in Mice Through Smad3-Dependent Signaling.

Extent of Detached Retina and Lens Status Influence Intravitreal Protein Expression in Rhegmatogenous Retinal Detachment.

Protective Effects of L-Carnitine Against Oxidative Injury by Hyperosmolarity in Human Corneal Epithelial Cells.

Assessment of Lens Center Using Optical Coherence Tomography, Magnetic Resonance Imaging, and Photographs of the Anterior Segment of the Eye.

Reactivation of the PI3K/Akt Signaling Pathway by the Bisperoxovanadium Compound bpV(pic) Attenuates Photoreceptor Apoptosis in Experimental Retinal Detachment.

Perceptual Visual Distortions in Adult Amblyopia and Their Relationship to Clinical Features.

Tolerance and Relative Utility: Two Proposed Indices for Comparing Change in Clinical Measurement Noise Between Different Populations (Repeatability) or Measurement Methods (Agreement).

Evaluation of the Structure-Function Relationship in Glaucoma Using a Novel Method for Estimating the Number of Retinal Ganglion Cells in the Human Retina.

Corneal Deformation Response in Patients With Primary Open-Angle Glaucoma and in Healthy Subjects Analyzed by Corvis ST.

Molecular Inflammation in the Contralateral Eye After Cataract Surgery in the First Eye.

Intraocular Pharmacokinetics of Aflibercept and Vascular Endothelial Growth Factor-A.

Inhibition of DNA Methylation and Methyl-CpG-Binding Protein 2 Suppresses RPE Transdifferentiation: Relevance to Proliferative Vitreoretinopathy.

Associations Between the T280M and V249I SNPs in CX3CR1 and the Risk of Age-Related Macular Degeneration.

Genetic Evidence for Differential Regulation of Corneal Epithelial and Stromal Thickness

Genomic Copy Number Variations of the Complement Component C4B Gene Are Associated With Chronic Central Serous Chorioretinopathy.

The Antioxidant N-Acetylcysteine Inhibits Inflammatory and Apoptotic Processes in Human Conjunctival Epithelial Cells in a High-Glucose Environment.

Second Harmonic Generation Imaging Analysis of Collagen Arrangement in Human Cornea.

The Relationship Between Visual Acuity and the Reproducibility of Visual Field Measurements in Glaucoma Patients.

The Reliability and Reproducibility of Corneal Confocal Microscopy in Children.

Neuroprotective Effects of Human Serum Albumin Nanoparticles Loaded With Brimonidine on Retinal Ganglion Cells in Optic Nerve Crush Model.

Analysis of Changes in Refraction and Biometry of Atropine- and Placebo-Treated Eyes.

Hic-5 Regulates Actin Cytoskeletal Reorganization and Expression of Fibrogenic Markers and Myocilin in Trabecular Meshwork Cells.

Diagnosis of Early-Stage Glaucoma by Grid-Wise Macular Inner Retinal Layer Thickness Measurement and Effect of Compensation of Disc-Fovea Inclination.

Comparing the Hem- and Lymphangiogenic Profile of Conjunctival and Uveal Melanoma Cell Lines.

Metabolomic Analysis of Human Vitreous in Rhegmatogenous Retinal Detachment Associated With Choroidal Detachment.

Does Myopia Affect Angle Closure Prevalence.

Characterization of Retinal Disease Progression in a 1-Year Longitudinal Study of Eyes With Mild Nonproliferative Retinopathy in Diabetes Type 2.

Year: 2015 Volume: 56 Issue: 8

Year: 2015 Volume: 56 Issue: 6

Year: 2015 Volume: 56 Issue: 5

Year: 2015 Volume: 56 Issue: 4

Year: 2015 Volume: 56 Issue: 3

Year: 2015 Volume: 56 Issue: 2

Year: 2015 Volume: 56 Issue: 1

Year: 2014 Volume: 56

Year: 2014 Volume: 55

Year: 2013 Volume: 54

Year: 2012 Volume: 53

Year: 2011 Volume: 52

Year: 2010 Volume: 51

Year: 2009 Volume: 50

Year: 2008 Volume: 49

Characterization of Retinal Disease Progression in a 1-Year Longitudinal Study of Eyes With Mild Nonproliferative Retinopathy in Diabetes Type 2.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Vujosevic, Stela Menon, Geeta Martinez, Jose P. Tejerina, Amparo Navea Wiedemann, Peter Coriat, Caroline Sivaprasad, Sobha Verbraak, Frank D. Cunha-Vaz, José Holz, Frank G. Smets, Erica Querques, Giuseppe Ágoas, Victor Bandello, Francesco Lund-Andersen, Henrik Jürgens, Ignasi Nunes, Sandrina Ribeiro, Luisa Massin, Pascale Varano, Monica Egan, Catherine Neves, Catarina
Description	Country affiliation: Portugal Author Affiliation: Ribeiro L ( Association for Innovation and Biomedical Research on Light and Image (AIBILI) Coimbra, Portugal.); Bandello F ( Department of Ophthalmology, University Vita Salute-Scientific Institute of San Raffael, Milan, Italy.); Tejerina AN ( Fundación para la Investigacion Biomedica y Sanitaria, FISABIO-OFTALMOLOGIA, Valencia, Spain.); Vujosevic S ( Centre for Clinical Trials, Department of Ophthalmology, University of Padova, Padova, Italy.); Varano M ( G.B. Bietti Eye Foundation-IRCCS, Rome, Italy.); Egan C ( Clinical Trials Unit, Moorfields Eye Hospital, NHS Foundation Trust, London, United Kingdom.); Sivaprasad S ( Laser and Retinal Research Unit, King's Health Partners, London, United Kingdom.); Menon G ( Ophthalmology Clinical Trials Unit, Frimley Park Hospital Foundation Trust, Frimley, United Kingdom.); Massin P ( Department of Ophthalmology, Lariboisière Hospital, Paris, France.); Verbraak FD ( Department of Ophthalmology, Academic Medical Center, Amsterdam, The Netherlands.); Lund-Andersen H ( Department of Ophthalmology, Glostrup Hospital, Copenhagen University, Glostrup, Denmark.); Martinez JP ( Rotterdam Eye Hospital, Rotterdam, The Netherlands.); Jürgens I ( Institut Català de Retina (ICR), Barcelona, Spain.); Smets E ( Antwerp University Hospital, Department of Ophthalmology, Antwerp, Belgium.); Coriat C ( Centre d'Investigation Clinique, Centre National d'Ophtalmologie des Quinze-Vingts, Paris, France.); Wiedemann P ( University Eye Hospital Leipzig, Leipzig, Germany.); Ágoas V ( Instituto de Oftalmologia Dr. Gama Pinto, Lisboa, Portugal.); Querques G ( Centre Hospitalier Intercommunal de Creteil, University Paris-Est Creteil, Creteil, France.); Holz FG ( Department of Ophthalmology, University of Bonn, Bonn, Germany.); Nunes S ( Association for Innovation and Biomedical Research on Light and Image (AIBILI) Coimbra, Portugal.); Neves C ( Association for Innovation and Biomedical Research on Light and Image (AIBILI) Coimbra, Portugal.); Cunha-Vaz J ( Association for Innovation and Biomedical Research on Light and Image (AIBILI) Coimbra, Portugal.)
Abstract	PURPOSE: To identify eyes of patients with diabetes type 2 that show progression of retinal disease within a 1-year period using noninvasive techniques. METHODS: Three hundred seventy-four type 2 diabetic patients with mild nonproliferative diabetic retinopathy (Early Treatment Diabetic Retinopathy Study [ETDRS] level 20 or 35) were included in a 12-month prospective observational study to identify retinopathy progression. Four visits were scheduled at 0, 3, 6, and 12 months. Microaneurysm (MA) activity using the RetmarkerDR and retinal thickness using spectral-domain optical coherence tomography (SD-OCT) were assessed by a central reading center at all visits and ETDRS severity level in the first and last visits. RESULTS: Three hundred thirty-one eyes/patients completed the study. Microaneurysm formation rate greater than or equal to 2 was present in 68.1% of the eyes and MA turnover greater than or equal to 6 in 54.0% at month 6. Higher MA turnover values were registered in eyes that showed progression in ETDRS severity level (P < 0.03). There were also significant correlations between increased microaneurysm activity and increases in retinal thickness. Spectral-domain OCT identified clinical macular edema in 24 eyes/patients (6.7%) and subclinical macular edema in 104 eyes/patients (28.9%) at baseline. Progression of retinal thickening was registered in eyes that had either subclinical or clinical macular edema at baseline. CONCLUSIONS: Changes in MA activity measured with RetmarkerDR and in central retinal thickness in eyes with mild nonproliferative diabetic retinopathy and diabetes type 2 are able to identify eyes at risk of progression. These eyes/patients should be selected for inclusion in future clinical trials of drugs targeted to prevent diabetic retinopathy progression to vision-threatening complications. (ClinicalTrials.gov number, NCT01145599.)
ISSN	01460404
e-ISSN	15525783
Journal	Investigative Opthalmology & Visual Science
Issue Number	9
Volume Number	56
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2015-08-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Diabetes Mellitus, Type 2 Complications Diabetic Retinopathy Diagnosis Retina Pathology Tomography, Optical Coherence Visual Acuity Etiology Physiopathology Disease Progression Prognosis Prospective Studies Time Factors Multicenter Study Observational Study Randomized Controlled Trial Research Support, Non-u.s. Gov't Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in