NDLI: Ovar-Mhc - ovine major histocompatibility complex: structure and gene polymorphisms

Please wait, while we are loading the content...

Phylogeography of Brachyplatystoma rousseauxii (Siluriformes - Pimelodidae) in the Amazon Basin offers preliminary evidence for the first case of [quot ]homing[quot ] for an Amazonian migratory catfish

The Star STING server: a multiplatform environment for protein structure analysis

Hemoglobin I-Philadelphia [alpha 16 (A14) LYS-->GLU] heterozygote among blood donors from Brazil

Comparative analysis of human masculinity

Cassava in South America, Brazil's contribution and the lesson to be learned from India

The Candida albicans AAA ATPase homologue of Saccharomyces cerevisiae Rix7p (YLL034c) is essential for proper morphology, biofilm formation and activity of secreted aspartyl proteinases

Construction and partial characterization of a Corynebacterium pseudotuberculosis bacterial artificial chromosome library through genomic survey sequencing

Use of RAPD fingerprinting for delineating populations of hilsa shad Tenualosa ilisha (Hamilton, 1822)

Congenital bilateral anorchia: hormonal, molecular and imaging study of a case

New evidence for nucleolar dominance in hybrids of Drosophila arizonae and Drosophila mulleri

Genuine Bayesian multiallelic significance test for the Hardy-Weinberg equilibrium law

Identification of a new Schistosoma mansoni membrane-bound protein through bioinformatic analysis

Ovar-Mhc - ovine major histocompatibility complex: structure and gene polymorphisms

Genetic correlation between heifer pregnancy and scrotal circumference measured at 15 and 18 months of age in Nellore cattle

Genetic diversity in wild (Sus scrofa scrofa) and domestic (Sus scrofa domestica) pigs and their hybrids based on polymorphism of a fragment of the D-loop region in the mitochondrial DNA

Year: 2006 Volume: 5 Issue: 3

Year: 2006 Volume: 5 Issue: 2

Year: 2006 Volume: 5 Issue: 1

Ovar-Mhc - ovine major histocompatibility complex: structure and gene polymorphisms

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Dukkipati, V. S. Murray, A. Blair, H. T. Garrick, D. J.
Description	Country affiliation: New Zealand Responsible library: BR1.1 Author Affiliation: Dukkipati, V. S ( Massey University. Institute of Veterinary, Animal and Biomedical Sciences. Palmerston North. NZ); Murray, A ( Massey University. Institute of Veterinary, Animal and Biomedical Sciences. Palmerston North. NZ); Garrick, D. J ( Massey University. Institute of Veterinary, Animal and Biomedical Sciences. Palmerston North. NZ); Blair, H. T ( Massey University. Institute of Veterinary, Animal and Biomedical Sciences. Palmerston North. NZ)
Abstract	The major histocompatibility complex (MHC) in sheep, Ovar-Mhc, is poorly characterised, when compared to other domestic animals. However, its basic structure is similar to that of other mammals, comprising class I, II and III regions. Currently, there is evidence for the existence of four class I loci. The class II region is better characterised, with evidence of one DRA, four DRB (one coding and three non-coding), one DQA1, two DQA2, and one each of the DQB1, DQB2, DNA, DOB, DYA, DYB, DMA, and DMB genes in the region. The class III region is the least characterised, with the known presence of complement cascade (C4, C2 and Bf), TNFalpha and CYP21 genes. Products of the class I and II genes, MHC molecules, play a pivotal role in antigen presentation required for eliciting immune responses against invading pathogens. Several studies have focused on polymorphisms of Ovar-Mhc genes and their association with disease resistance. However, more research emphasis is needed on characterising the remaining Ovar-Mhc genes and developing simplified and cost-effective methods to score gene polymorphisms. Haplotype screening, employing multiple markers rather than single genes, would be more meaningful in MHC-disease association studies, as it is well known that most of the MHC loci are tightly linked, exhibiting very little recombination. This review summarises the current knowledge of the structure of Ovar-Mhc and polymorphisms of genes located in the complex.
e-ISSN	16765680
Journal	Genetics and Molecular Research
Issue Number	4
Volume Number	5
Language	English
Publisher	Fundação de Pesquisas Científicas de Ribeirão Preto
Publisher Place	Brazil
Access Restriction	Open
Subject Keyword	Animals Mice Histocompatibility Antigens Class I Genetics Histocompatibility Antigens Class Ii Immunity, Innate Polymorphism, Genetic Sheep Diseases Hla Antigens Haplotypes Immunology Structure-activity Relationship Discipline Genetics Discipline Molecular Biology Discipline Bioinformatics
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Long-range multilocus haplotype phasing of the MHC.

Genetic characterization of FLA, the cat major histocompatibility complex.

MICA polymorphisms and haplotypes with HLA-B and HLA-DRB1 in Koreans.

HLA polymorphisms in Sindhi community in Mumbai, India.

Genetic variation and hitchhiking between structurally polymorphic Alu insertions and HLA-A, -B, and -C alleles and other retroelements within the MHC class I region.

A primate species with limited major histocompatibility complex class I polymorphism.

Towards a systems understanding of MHC class I and MHC class II antigen presentation.

Major histocompatibility complex haplotypes and class II genes in non-Jewish patients with pemphigus vulgaris.

Fine mapping major histocompatibility complex associations in psoriasis and its clinical subtypes.

Ovar-Mhc - ovine major histocompatibility complex: structure and gene polymorphisms

Similar Documents

Long-range multilocus haplotype phasing of the MHC.

Genetic characterization of FLA, the cat major histocompatibility complex.

MICA polymorphisms and haplotypes with HLA-B and HLA-DRB1 in Koreans.

HLA polymorphisms in Sindhi community in Mumbai, India.

Genetic variation and hitchhiking between structurally polymorphic Alu insertions and HLA-A, -B, and -C alleles and other retroelements within the MHC class I region.

A primate species with limited major histocompatibility complex class I polymorphism.

Towards a systems understanding of MHC class I and MHC class II antigen presentation.

Major histocompatibility complex haplotypes and class II genes in non-Jewish patients with pemphigus vulgaris.

Fine mapping major histocompatibility complex associations in psoriasis and its clinical subtypes.

Ovar-Mhc - ovine major histocompatibility complex: structure and gene polymorphisms