NDLI: Investigation of ABCB1 gene polymorphism with colchicine response in Behçet's disease.

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Investigation of ABCB1 gene polymorphism with colchicine response in Behçet's disease.

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Investigation of ABCB1 gene polymorphism with colchicine response in Behçet's disease.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Yakut, T. Aydogan, K. Ozturk, H. Z. Y. Saricaoglu, H. Yilmaz, M. Karkucak, M. Gulten, T. Baskan, E. B. Dilek, K.
Description	Country affiliation: Turkey Author Affiliation: Saricaoglu H ( Department of Dermatology, Uludag University, Bursa, Turkey.)
Abstract	Colchicine is commonly used in the treatment of Behçet's disease. However, some patients are unresponsive to colchicine treatment. Adenosine triphosphate-binding cassette subfamily B member 1 (ABCB1) transports colchicine out of cells. We investigated a possible association of C3435T polymorphism of the ABCB1 (MDR1) gene with colchicine response in patients with Behçet's disease. We randomly selected 97 patients with Behçet's disease, examined ABCB1 (MDR1) gene C3435T polymorphisms, and evaluated patient responses to colchicine. Forty-three patients were colchicine responsive, while the remaining 54 patients were unresponsive. No significant difference was found between genotypic and allelic frequencies of the ABCB1 C3435T polymorphisms in patients with Behçet's disease and healthy volunteers. Also, there was no significant difference among responsive and nonresponsive patients. We concluded that ABCB1 C3435T polymorphism is not associated with a colchicine response in patients with Behçet's disease.
e-ISSN	16765680
Journal	Genetics and Molecular Research
Issue Number	1
Volume Number	10
Language	English
Publisher	Fundação de Pesquisas Científicas de Ribeirão Preto
Publisher Date	2011-01-04
Publisher Place	Brazil
Access Restriction	Open
Subject Keyword	Behcet Syndrome Drug Therapy Genetics P-glycoprotein Polymorphism, Single Nucleotide Case-control Studies Colchicine Therapeutic Use Gene Frequency Genotype Discipline Genetics Discipline Molecular Biology Discipline Bioinformatics
Content Type	Text
Resource Type	Article

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