NDLI: Short aggrecan gene repetitive alleles associated with lumbar degenerative disc disease in Turkish patients.

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Short aggrecan gene repetitive alleles associated with lumbar degenerative disc disease in Turkish patients.

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Short aggrecan gene repetitive alleles associated with lumbar degenerative disc disease in Turkish patients.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Yildiz, H. Haktanir, A. Cosar, M. Erdogan, M. O. Eser, B. Aslan, A. Eser, O. Solak, M.
Spatial Coverage	Turkey
Description	Country affiliation: Turkey Author Affiliation: Eser O ( Department of Neurosurgery, Afyon Kocatepe University, Afyonkarahisar, Turkey. drolcayeser@hotmail.com)
Abstract	We investigated a possible association between aggrecan gene polymorphism and lumbar degenerative disc disease in Turkish patients. One hundred 20-30-year-old patients with or without low back pain were selected for the study. Lumbar magnetic resonance imaging was performed on all patients. The patient group had low back pain clinically and degenerative disc disease radiographically. The control group included patients with and without low back pain: all were negative radiographically for degenerative disc disease. Genomic DNA was extracted from all participants. A PCR assay were used to evaluate variable number of tandem repeat polymorphism of aggrecan gene alleles to determine if there was any correlation with degenerative disc disease. Significant associations were found between short repeated alleles of the aggrecan gene and severe disc degeneration. A significant association was also found between short repeated alleles of the aggrecan gene and multilevel disc herniation as well as extrusion and sequestration types of disc herniation. In Turkish population, short repeated alleles of the aggrecan gene are associated with increased disc degeneration and disc herniation.
e-ISSN	16765680
Journal	Genetics and Molecular Research
Issue Number	3
Volume Number	10
Language	English
Publisher	Fundação de Pesquisas Científicas de Ribeirão Preto
Publisher Date	2011-08-30
Publisher Place	Brazil
Access Restriction	Open
Subject Keyword	Aggrecans Genetics Intervertebral Disc Degeneration Pathology Lumbar Vertebrae Alleles Extracellular Matrix Low Back Pain Magnetic Resonance Imaging Minisatellite Repeats Polymorphism, Single Nucleotide Repetitive Sequences, Nucleic Acid Turkey Research Support, Non-u.s. Gov't Discipline Genetics Discipline Molecular Biology Discipline Bioinformatics
Content Type	Text
Resource Type	Article

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