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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Palabiyik, B. Temizkan, G. Suslu, K. G. |
| Description | Country affiliation: Turkey Author Affiliation: Suslu KG ( Department of Molecular Biology and Genetics, Faculty of Science, Istanbul University, Istanbul, Turkey.) |
| Abstract | We looked for changes in gene expression and novel genes that could be involved in the interaction between glucose repression and oxidative stress response in the fission yeast, Schizosaccharomyces pombe, using a constitutive invertase mutant, ird11, which is resistant to glucose. BLAST analysis was made of the S. pombe genome database of cDNAs whose expression ratios differentially decreased or increased upon exposure to mild oxidative stress in this mutant compared to the wild type. Genes with this type of activity were identified as rpl302, encoding 60S ribosomal protein L3, and mpg1, encoding mannose-1-phosphate guanyltransferase; their expression patterns were measured using quantitative real-time PCR. We found that the expression levels of rpl302 and mpg1 genes in ird11 under unstressed conditions were increased compared to those of the wild type. Under stress conditions, the expression levels of the rpl302 gene were decreased in both strains, while mpg1 expression levels remained unchanged. These results suggest that these genes play a role in the response to oxidative stress in this mutant strain. |
| e-ISSN | 16765680 |
| Journal | Genetics and Molecular Research |
| Issue Number | 4 |
| Volume Number | 10 |
| Language | English |
| Publisher | Fundação de Pesquisas Científicas de Ribeirão Preto |
| Publisher Date | 2011-11-08 |
| Publisher Place | Brazil |
| Access Restriction | Open |
| Subject Keyword | Genes, Fungal Glucose Metabolism Ribosomal Proteins Genetics Schizosaccharomyces Pombe Proteins Schizosaccharomyces Dna, Complementary Gene Expression Regulation, Fungal Genome, Fungal Nucleotidyltransferases Oxidative Stress Research Support, Non-u.s. Gov't Discipline Genetics Discipline Molecular Biology Discipline Bioinformatics |
| Content Type | Text |
| Resource Type | Article |
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