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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Awad, S. I. Al-Sawah, G. A. Badawy, A. A. Yahya, R. S. Kizilbash, N. A. |
| Description | Country affiliation: Egypt Author Affiliation: Badawy AA ( Department of Medical Biochemistry, Faculty of Medicine, Mansoura University, Mansoura, Egypt.) |
| Abstract | Infection of mothers with schistosomiasis and filariasis has been shown to influence infant responses to neonatal Bacille Calmette-Guérin (BCG) immunization. The genetic makeup of infants is also considered an important determinant for the activity of BCG vaccine. The effect of natural resistance-associated macrophage protein 1 (NRAMP1) gene polymorphism on the efficacy of BCG vaccine was examined in neonates with helminth-infected mothers (63 infants) and the results were compared with neonates of uninfected mothers (187 infants). After BCG vaccination, assessment of scar presence, tuberculin test, stool analysis, and IgE level was performed. Polymorphism of the NRAMP1 gene was investigated by PCR amplification followed by RFLP analysis. We found that patients with heterozygosity of intron 4 (GC) and/or maternal infection with helminth parasites showed reduced efficacy of BCG vaccine against tuberculosis. |
| e-ISSN | 16765680 |
| Journal | Genetics and Molecular Research |
| Issue Number | 3 |
| Volume Number | 12 |
| Language | English |
| Publisher | Fundação de Pesquisas Científicas de Ribeirão Preto |
| Publisher Date | 2013-01-30 |
| Publisher Place | Brazil |
| Access Restriction | Open |
| Subject Keyword | Bcg Vaccine Administration & Dosage Cation Transport Proteins Genetics Tuberculosis Immunology Animals Filariasis Parasitology Prevention & Control Helminths Pathogenicity Infant, Newborn Polymorphism, Restriction Fragment Length Schistosoma Mansoni Drug Effects Schistosomiasis Wuchereria Bancrofti Discipline Genetics Discipline Molecular Biology Discipline Bioinformatics |
| Content Type | Text |
| Resource Type | Article |
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