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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Rainho, C. R. Mazzei, J. L. Aiub, C. A. F. Corrêa, S. M. Felzenszwalb, I. |
| Description | Country affiliation: Brazil Author Affiliation: Rainho CR ( Laboratório de Mutagênese Ambiental, Departamento de Biofísica e Biometria, Instituto de Biologia Roberto Alcântara Gomes, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.); Corrêa SM ( Departamento de Química Ambiental, Faculdade de Tecnologia, Universidade do Estado do Rio de Janeiro, Resende, RJ, Brasil.); Mazzei JL ( Fundação Oswaldo Cruz, Farmanguinhos Plataforma de Métodos Analíticos, Rio de Janeiro, RJ, Brasil.); Aiub CA ( Laboratório de Genotoxicidade, Departamento de Genética e Biologia Molecular, Instituto Biomédico, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.); Felzenszwalb I ( Laboratório de Mutagênese Ambiental, Departamento de Biofísica e Biometria, Instituto de Biologia Roberto Alcântara Gomes, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brasil uerj.felzen@gmail.com.) |
| Abstract | The use of strains of Salmonella enterica serovar Typhimurium with different metabolic capacities can indicate the class or classes of compounds present in an environmental sample and enable the diagnosis of the mutagenic activity of these pollutants adsorbed on particulate matter (PM) in the air. In the present study, the sensitivity of Salmonella strains TA98NR, TA98/1,8-DNP6, YG1021, and YG1024 to detect nitro compounds adsorbed on samples of PM 2.5 was compared from three sites in Rio de Janeiro city. Samples were collected using a high-volume sampler at three sites: one with light traffic and two with heavy traffic. The assays were performed in the presence of 10-50 µg/ plate organic extracts with and without exogenous metabolization. The YG1021 and YG1024 strains showed the highest rev/m(3) values, confirming their enhanced sensitivity. As YG1024 also demonstrated sensitivity to nitro and amino compounds, we suggest its use in research into environmental contamination. |
| e-ISSN | 16765680 |
| Journal | Genetics and Molecular Research |
| Issue Number | 2 |
| Volume Number | 13 |
| Language | English |
| Publisher | Fundação de Pesquisas Científicas de Ribeirão Preto |
| Publisher Date | 2014-05-09 |
| Publisher Place | Brazil |
| Access Restriction | Open |
| Subject Keyword | Air Pollutants Toxicity Mutagens Nitro Compounds Salmonella Typhi Drug Effects Mutagenicity Tests Genetics Research Support, Non-u.s. Gov't Discipline Genetics Discipline Molecular Biology Discipline Bioinformatics |
| Content Type | Text |
| Resource Type | Article |
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