NDLI: Polychlorinated biphenyl (118) activates osteoclasts and induces bone resorption in goldfish.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Tsurukawa, Masahiro Hayakawa, Kazuichi Hattori, Atsuhiko Sekiguchi, Toshio Wada, Shigehito Suzuki, Motoharu Matsumura, Chisato Chiba, Atsuhiko Endo, Masato Tabuchi, Yoshiaki Haga, Yuki Nakano, Takeshi Kondo, Takashi Chowdhury, Vishwajit S. Okuno, Toshihiro Yachiguchi, Koji Mishima, Hiroyuki Nakano, Masaki Suzuki, Nobuo Kawabe, Kimi Toriba, Akira Kitamura, Kei-ichiro Matsumoto, Noriko
Description	Country affiliation: Japan Author Affiliation: Yachiguchi K ( Noto Marine Laboratory, Institute of Nature and Environmental Technology, Kanazawa University, Ogi, Noto-cho, Housu-gun, Ishikawa, 927-0553, Japan.)
Abstract	To analyze the effect of polychlorinated biphenyl (PCB) 118 on fish bone metabolism, we examined osteoclastic and osteoblastic activities, as well as plasma calcium levels, in the scales of PCB (118)-injected goldfish. In addition, effect of PCB (118) on osteoclasts and osteoblasts was investigated in vitro. Immature goldfish, in which the endogenous effects of sex steroids are negligible, were used. PCB (118) was solubilized in dimethyl sulfoxide at a concentration of 10 ppm. At 1 and 2 days after PCB (118) injection (100 ng/g body weight), both osteoclastic and osteoblastic activities, and plasma calcium levels were measured. In an in vitro study, then, both osteoclastic and osteoblastic activities as well as each marker mRNA expression were examined. At 2 days, scale osteoclastic activity in PCB (118)-injected goldfish increased significantly, while osteoblastic activity did not change significantly. Corresponding to osteoclastic activity, plasma calcium levels increased significantly at 2 days after PCB (118) administration. Osteoclastic activation also occurred in the marker enzyme activities and mRNA expressions in vitro. Thus, we conclude that PCB (118) disrupts bone metabolism in goldfish both in vivo and in vitro experiments.
ISSN	09441344
e-ISSN	16147499
DOI	10.1007/s11356-012-1347-5
Journal	Environmental Science and Pollution Research
Issue Number	10
Volume Number	21
Language	English
Publisher	Springer
Publisher Date	2014-05-01
Publisher Place	Germany
Access Restriction	Open
Subject Keyword	Osteoclasts Physiology Polychlorinated Biphenyls Toxicity Water Pollutants, Chemical Animals Bone Resorption Metabolism Osteoblasts Drug Effects Research Support, Non-u.s. Gov't Discipline Environmental Science Discipline Environmental Chemistry
Content Type	Text
Resource Type	Article
Subject	Environmental Chemistry Health, Toxicology and Mutagenesis Pollution Medicine

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