NDLI: Acute crack cocaine exposure induces genetic damage in multiple organs of rats.

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Acute crack cocaine exposure induces genetic damage in multiple organs of rats.

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Acute crack cocaine exposure induces genetic damage in multiple organs of rats.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Moretti, Eduardo Gregolin Pereira, Camilo Dias Seabra Ribeiro, Daniel Araki Vilegas, Wagner Claudio, Samuel Rangel Silva, Marcelo Jose Dias de Oliveira, Flavia Yujra, Veronica Quispe
Description	Country affiliation: Brazil Author Affiliation: Moretti EG ( Departamento de Biociências, Universidade Federal de São Paulo-UNIFESP, Av. Ana Costa 95, Zip Code 11060-001, Santos, SP, Brazil.); Yujra VQ ( Department of Pathology, Federal University of Sao Paulo, UNIFESP, Santos, SP, Brazil.); Claudio SR ( Departamento de Biociências, Universidade Federal de São Paulo-UNIFESP, Av. Ana Costa 95, Zip Code 11060-001, Santos, SP, Brazil.); Silva MJ ( Sao Paulo State University, UNESP, Campus Litoral Paulista, Sao Vicente, SP, Brazil.); Vilegas W ( Sao Paulo State University, UNESP, Campus Litoral Paulista, Sao Vicente, SP, Brazil.); Pereira CD ( Department of Sea Sciences, Federal University of Sao Paulo, UNIFESP, Santos, SP, Brazil.); de Oliveira F ( Departamento de Biociências, Universidade Federal de São Paulo-UNIFESP, Av. Ana Costa 95, Zip Code 11060-001, Santos, SP, Brazil.); Ribeiro DA ( Departamento de Biociências, Universidade Federal de São Paulo-UNIFESP, Av. Ana Costa 95, Zip Code 11060-001, Santos, SP, Brazil. daribeiro@unifesp.br.)
Abstract	Crack cocaine is a very toxic product derived from cocaine. The aim of this study was to evaluate genetic damage in multiple organs of rats following acute exposure to crack cocaine. A total of 20 Wistar rats were distributed into four groups (n = 5), as follows: 0, 4.5, 9, and 18 mg/kg body weight (b.w.) of crack cocaine administered by intraperitoneal route (i.p.). All animals were killed 24 h after intraperitoneal (i.p.) injection. The results showed that crack cocaine increased the number of micronucleated cells in bone marrow cells exposed to 18 mg/kg crack cocaine (p < 0.05). Peripheral blood and liver cells presented genetic damage as depicted by single cell gel (comet) assay at 9 and 18 mg/kg doses (p < 0.05). Immunohistochemistry data revealed significant increase in 8-hydroxy-20-deoxyguanosine (8-OHdG) immunoexpression in hepatocytes of animals exposed to crack cocaine at 9 and 18 mg/kg (p < 0.05) when compared with negative controls. Taken together, our results demonstrate that crack cocaine is able to induce genomic damage in multiple organs of Wistar rats.
ISSN	09441344
Issue Number	8
Journal	Environmental Science and Pollution Research
Volume Number	23
e-ISSN	16147499
Language	English
Publisher	Springer
Publisher Date	2016-04-01
Publisher Place	Germany
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Environmental Science Discipline Environmental Chemistry
Content Type	Text
Resource Type	Article
Subject	Environmental Chemistry Health, Toxicology and Mutagenesis Pollution Medicine

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