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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Organization | European Concerted Action on New Generation Genetic Markers and Techniques for the Epidemiology and Control of Tuberculosis |
| Abstract | Beijing/W genotype Mycobacterium tuberculosis is widespread, may be increasing, and may have a predilection for drug resistance. Individual-level data on >29,000 patients from 49 studies in 35 countries were combined to assess the Beijing genotype's prevalence worldwide, trends over time and with age, and associations with drug resistance. We found 4 patterns for Beijing/W genotype tuberculosis (TB): 1) endemic, not associated with drug resistance (high level in most of East Asia, lower level in parts of the United States); 2) epidemic, associated with drug resistance (high level in Cuba, the former Soviet Union, Vietnam, and South Africa, lower level in parts of Western Europe); 3) epidemic but drug sensitive (Malawi, Argentina); and 4) very low level or absent (parts of Europe, Africa). This study confirms that Beijing/W genotype TB is an emerging pathogen in several areas and a predominant endemic strain in others; it is frequently associated with drug resistance. |
| ISSN | 10806040 |
| e-ISSN | 10806059 |
| Journal | Emerging Infectious Diseases |
| Issue Number | 5 |
| Volume Number | 12 |
| Language | English |
| Publisher | Centers for Disease Control and Prevention |
| Publisher Date | 2006-05-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Antitubercular Agents Therapeutic Use Global Health Mycobacterium Tuberculosis Drug Effects Genetics Tuberculosis, Multidrug-resistant Epidemiology Tuberculosis Communicable Diseases, Emerging Drug Therapy Microbiology Drug Resistance, Multiple, Bacterial Genotype Meta-analysis Research Support, Non-u.s. Gov't Discipline Infectious Diseases |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Epidemiology Microbiology (medical) |
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