NDLI: Molecular Epidemiology of Plasmodium falciparum Malaria Outbreak, Tumbes, Peru, 2010-2012.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Salas, Carola Sánchez, Juan F. Edgel, Kimberly A. Macedo, Silvia Conde, Silvia Herrera, Yeni Gamboa, Dionicia Gonzalez, Rommell V. Tapia, L. Lorena Lescano, Andrés G. Baldeviano, G. Christian Arrospide, Nancy Okoth, Sheila Akinyi Udhayakumar, Venkatachalam
Spatial Coverage	Peru
Abstract	During 2010-2012, an outbreak of 210 cases of malaria occurred in Tumbes, in the northern coast of Peru, where no Plasmodium falciparum malaria case had been reported since 2006. To identify the source of the parasite causing this outbreak, we conducted a molecular epidemiology investigation. Microsatellite typing showed an identical genotype in all 54 available isolates. This genotype was also identical to that of parasites isolated in 2010 in the Loreto region of the Peruvian Amazon and closely related to clonet B, a parasite lineage previously reported in the Amazon during 1998-2000. These findings are consistent with travel history of index case-patients. DNA sequencing revealed mutations in the Pfdhfr, Pfdhps, Pfcrt, and Pfmdr1 loci, which are strongly associated with resistance to chloroquine and sulfadoxine/pyrimethamine, and deletion of the Pfhrp2 gene. These results highlight the need for timely molecular epidemiology investigations to trace the parasite source during malaria reintroduction events.
ISSN	10806040
e-ISSN	10806059
DOI	10.3201/eid2105.141427
Journal	Emerging Infectious Diseases
Issue Number	5
Volume Number	21
Language	English
Publisher	Centers for Disease Control and Prevention
Publisher Date	2015-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Disease Outbreaks Malaria, Falciparum Epidemiology Parasitology Plasmodium Falciparum Genetics Alleles Antimalarials Pharmacology Dna, Protozoan Drug Resistance Gene Deletion Genotype Geography Haplotypes History, 21st Century Microsatellite Repeats Molecular Epidemiology Drug Effects Protozoan Proteins Historical Article Research Support, N.i.h., Extramural Research Support, U.s. Gov't, Non-p.h.s. Discipline Infectious Diseases
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Epidemiology Microbiology (medical)

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