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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Limsakul, Chusak Suwansa-ard, Siriwan Kanatharana, Proespichaya Asawatreratanakul, Punnee Wongkittisuksa, Booncharoen Thavarungkul, Panote |
| Description | Country affiliation: Thailand Author Affiliation: Suwansa-ard S ( Trace Analysis and Biosensor Research Center, Department of Chemistry, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand.) |
| Abstract | This paper presents a comparison between surface plasmon resonance (SPR) and capacitive immunosensors for a flow injection label-free detection of cancer antigen 125 (CA 125) in human serum. Anti-CA 125 was immobilized on gold surface through a self-assembled monolayer. Parameters affecting the responses of each system were optimized. Under optimal conditions, SPR provided a detection limit of 0.1 U ml(-1) while 0.05 U ml(-1) was obtained for the capacitive system. Linearity for SPR was between 0.1 and 40 U ml(-1) and 0.05-40 U ml(-1) for capacitive system. These immunosensors were applied to analyze CA 125 concentrations in human serum samples and compared with conventional enzyme linked fluorescent assay (ELFA). Both systems showed good agreement with ELFA (P<0.05). Moreover, these immunosensors were very stable and provided good reproducible responses after regeneration, up to 32 times for SPR and 48 times for capacitive system with relative standard deviation lower than 4%. The SPR immunosensor provided advantages in term of fast response and real-time monitoring while capacitive immunosensor offered a sensitive and cost-effective method for CA 125 detection. |
| ISSN | 09565663 |
| Issue Number | 12 |
| Volume Number | 24 |
| e-ISSN | 18734235 |
| Journal | Biosensors and Bioelectronics |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2009-08-15 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Tumor Markers, Biological Blood Biosensing Techniques Instrumentation Blood Chemical Analysis Ca-125 Antigen Electrochemistry Ovarian Neoplasms Diagnosis Surface Plasmon Resonance Electric Capacitance Equipment Design Equipment Failure Analysis Female Humans Neoplasm Proteins Analysis Reproducibility Of Results Sensitivity And Specificity Comparative Study Evaluation Studies Journal Article Research Support, Non-u.s. Gov't Discipline Biotechnology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nanoscience and Nanotechnology Medicine Biophysics Biomedical Engineering Biotechnology Electrochemistry |
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