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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Hall, D. A. Osterfeld, S. J. Gaster, R. S. Wang, S. X. Murmann, B. |
| Description | Country affiliation: United States Author Affiliation: Hall DA ( Department of Electrical Engineering, Stanford University, Stanford, CA 94305, USA.) |
| Abstract | Giant magnetoresistive biosensors possess great potential in biomedical applications for quantitatively detecting magnetically tagged biomolecules. Magnetic sensing does not suffer from the high background levels found in optical sensing modalities such as the enzyme linked immunosorbent assay translating into a technology with higher sensitivity. However, to reveal the full potential of these sensors and compensate for non-idealities such as temperature dependence, digital correction and calibration techniques are not only useful but imperative. Using these calibration techniques to correct for process variations and dynamic changes in the sensing environment (such as temperature and magnetic field), we are able to obtain extremely sensitive and, more importantly, reproducible results for quantifiable biomolecular reorganization. The reproducibility of the system was improved by over 3 x using digital correction techniques and the sensors are made temperature independent by using a novel background correction technique. |
| ISSN | 09565663 |
| e-ISSN | 18734235 |
| DOI | 10.1016/j.bios.2010.01.039 |
| Journal | Biosensors and Bioelectronics |
| Issue Number | 9 |
| Volume Number | 25 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2010-05-15 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Biosensing Techniques Instrumentation Algorithms Statistics & Numerical Data Magnetics Proteins Reproducibility Of Results Temperature Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Research Support, U.s. Gov't, Non-p.h.s. Discipline Biotechnology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nanoscience and Nanotechnology Medicine Biophysics Biomedical Engineering Biotechnology Electrochemistry |
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