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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Marques, L. Hernandez, F. U. Clark, M. James, S. W. Korposh, S. Tatam, R. P. Morgan, S. P. |
| Description | Country affiliation: United kingdom Author Affiliation: Marques L ( Applied Optics Group, Faculty of Engineering, University of Nottingham, Nottingham NG7 2RD, UK.); Hernandez FU ( Applied Optics Group, Faculty of Engineering, University of Nottingham, Nottingham NG7 2RD, UK.); James SW ( Engineering Photonics, Cranfield University, Cranfield, Bedfordshire MK43 0AL, UK.); Morgan SP ( Applied Optics Group, Faculty of Engineering, University of Nottingham, Nottingham NG7 2RD, UK.); Clark M ( Applied Optics Group, Faculty of Engineering, University of Nottingham, Nottingham NG7 2RD, UK.); Tatam RP ( Engineering Photonics, Cranfield University, Cranfield, Bedfordshire MK43 0AL, UK.); Korposh S ( Applied Optics Group, Faculty of Engineering, University of Nottingham, Nottingham NG7 2RD, UK) |
| Abstract | An optical fibre long period grating (LPG), modified with a coating of silica core gold shell (SiO2:Au) nanoparticles (NPs) deposited using the layer-by-layer method, was employed for the development of a biosensor. The SiO2:Au NPs were electrostatically assembled onto the LPG with the aid of a poly(allylamine hydrochloride) (PAH) polycation layer. The LPG sensor operates at the phase matching turning point to provide the highest sensitivity. The SiO2:Au NPs were modified with biotin, which was used as a ligand for streptavidin (SV) detection. The sensing mechanism is based on the measurement of the refractive index change induced by the binding of the SV to the biotin. The effect on sensitivity of increasing the surface area by virtue of the SiO2:Au nanoparticles' diameter and film thickness was studied. The lowest measured concentration of SV was 2.5nM, achieved using an LPG modified with a 3 layer (PAH/SiO2:Au) thin film composed of SiO2 NPs of 300nm diameter with a binding constant of k=1.7(pM)(-1), sensitivity of 6.9nm/ng/mm(2) and limit of detection of 19pg/mm(2). |
| ISSN | 09565663 |
| Volume Number | 75 |
| e-ISSN | 18734235 |
| Journal | Biosensors and Bioelectronics |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-01-15 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Biosensing Techniques Metal Nanoparticles Chemistry Optical Fibers Biotin Gold Polyamines Silicon Dioxide Streptavidin Journal Article Research Support, Non-u.s. Gov't Discipline Biotechnology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nanoscience and Nanotechnology Medicine Biophysics Biomedical Engineering Biotechnology Electrochemistry |
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