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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Limem, Ilef Bouhlel, Ines Ghedira, Kamel Boubaker, Jihed Skandrani, Ines Kilani, Soumaya Neffatti, Aicha Bhouri, Wissem Dijoux-Franca, Marie Genviève Ben Sghaier, Mohamed Ben Ammar, Ribai Chekir-Ghedira, Leila |
| Description | Country affiliation: Tunisia Author Affiliation: Kilani S ( Unité de Pharmacognosie/Biologie Moléculaire 99/UR/07-03, Faculty of Pharmacy of Monastir, 5000 Monastir, Tunisia.) |
| Abstract | The in vitro antibacterial, antioxidant, cytotoxic and apoptotic activities from tubers extracts of Cyperus rotundus (Cyperaceae) were investigated. Antibacterial activity of different extracts was evaluated against five bacterial reference strains. A marked inhibitory effect was observed against Salmonella enteritidis, Staphylococcus aureus and Enterococcus faecalis with total oligomers flavonoids (TOFs) and ethyl acetate extracts. In addition to their antibacterial activity, the same extracts showed a significant ability to inhibit nitroblue tetrazolium reduction by the superoxide radical in a non-enzymatic superoxide generating system. Apoptosis, a highly organized physiological mechanism to eliminate injured or abnormal cells, is also implicated in multistage carcinogenesis. It was observed that TOF and ethyl acetate extracts suppressed growth and proliferation of L1210 cells derived from murine lymphoblastic leukaemia. Morphological features of treated cells and characteristic DNA fragmentation revealed that the cytotoxicity was due to induction of apoptosis. This study confirms that TOF and ethyl acetate extracts of C.rotundus possess antibacterial and antioxidant properties and provoke DNA fragmentation, a sign of induction of apoptosis. These results were correlated with chemical composition of the tested extracts. |
| ISSN | 09608524 |
| Issue Number | 18 |
| Volume Number | 99 |
| e-ISSN | 18732976 |
| Journal | Bioresource Technology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2008-12-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Anti-bacterial Agents Pharmacology Antioxidants Apoptosis Drug Effects Cyperus Metabolism Plant Extracts Plant Tubers Animals Bacteria Cell Line, Tumor Cell Proliferation Chemistry Dna Fragmentation Free Radical Scavengers Mice Microbial Sensitivity Tests Superoxides Journal Article Research Support, Non-u.s. Gov't Discipline Bioresource |
| Content Type | Text |
| Resource Type | Article |
| Subject | Waste Management and Disposal Medicine Environmental Engineering Renewable Energy, Sustainability and the Environment Bioengineering |
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