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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Chai, Zhifang Zhao, Yuliang Tian, Gan Gu, Zhanjun Li, Shoujian Yan, Liang |
| Description | Country affiliation: China Author Affiliation: Gu Z ( CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanosciences and Technology of China and Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing, China.) |
| Abstract | Lanthanide (Ln) doped upconversion nanoparticles (UCNPs) have attracted enormous attention in the recent years due to their unique upconversion luminescent properties that enable the conversion of low-energy photons (near infrared photons) into high-energy photons (visible to ultraviolet photons) via the multiphoton processes. This feature makes them ideal for bioimaging applications with attractive advantages such as no autofluorescence from biotissues and a large penetration depth. In addition, by incorporating advanced features, such as specific targeting, multimodality imaging and therapeutic delivery, the application of UCNPs has been dramatically expanded. In this review, we first summarize the recent developments in the fabrication strategies of UCNPs with the desired size, enhanced and tunable upconversion luminescence, as well as the combined multifunctionality. We then discuss the chemical methods applied for UCNPs surface functionalization to make these UCNPs biocompatible and water-soluble, and further highlight some representative examples of using UCNPs for in vivo bioimaging, NIR-triggered drug/gene delivery applications and photodynamic therapy. In the perspectives, we discuss the need of systematically nanotoxicology data for rational designs of UCNPs materials, their surface chemistry in safer biomedical applications. The UCNPs can actually provide an ideal multifunctionalized platform for solutions to many key issues in the front of medical sciences such as theranostics, individualized therapeutics, multimodality medicine, etc. |
| ISSN | 09359648 |
| Issue Number | 28 |
| Volume Number | 25 |
| e-ISSN | 15214095 |
| Journal | Advanced Materials |
| Language | English |
| Publisher | Wiley-VCH |
| Publisher Date | 2013-07-26 |
| Publisher Place | Germany |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Nanoparticles Therapeutic Use Nanotechnology Methods Safety Animals Humans Molecular Imaging Chemistry Toxicity Neoplasms Diagnosis Therapy Toxicity Tests Journal Article Research Support, Non-u.s. Gov't Review Discipline Materials Science |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nanoscience and Nanotechnology Mechanics of Materials Mechanical Engineering |
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