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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Morgan, Gareth Elwood, Peter C. Gallagher, Alison M. Mur, Luis A. J. Duthie, Garry G. |
| Description | Author Affiliation: Elwood PC ( School of Medicine, Cardiff University, Cardiff, UK.) |
| Abstract | Evidence from a wide range of sources suggests that individuals taking aspirin and related non-steroidal anti-inflammatory drugs have reduced risk of large bowel cancer. Work in animals supports cancer reduction with aspirin, but no long-term randomised clinical trials exist in human beings, and randomisation would be ethically unacceptable because vascular protection would have to be denied to a proportion of the participants. However, opportunistic trials of aspirin, designed to test vascular protection, provide some evidence of a reduction in cancer, but only after at least 10 years. We summarise evidence for the potential benefit of aspirin and natural salicylates in cancer prevention. Possible mechanisms of action and directions for further work are discussed, and implications for clinical practice are considered. |
| ISSN | 01406736 |
| e-ISSN | 1474547X |
| Journal | The Lancet |
| Issue Number | 9671 |
| Volume Number | 373 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2009-04-11 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Anti-Inflammatory Agents, Non-Steroidal Therapeutic Use Aspirin Evidence-Based Medicine Neoplasms Prevention & Control Animals Pharmacology Apoptosis Drug Effects Breast Neoplasms Case-Control Studies Cohort Studies Colonic Neoplasms Cyclooxygenase Inhibitors DNA Mismatch Repair Drug Evaluation, Preclinical Organization & Administration Intestinal Polyps Epidemiology Etiology Prostaglandin-Endoperoxide Synthases Prostatic Neoplasms Randomized Controlled Trials As Topic Risk Reduction Behavior Time Factors Medicine |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine |
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