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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Gonzalez-bonilla, Cesar Grajales-muñiz, Concepción Rascón-pacheco, Ramón Alberto Borja-aburto, Víctor Hugo González-león, Margot Mar-obeso, Alvaro J. Echevarría-zuno, Santiago Ortega-alvarez, Manuel Carlos Robles-pérez, Eduardo Mejía-aranguré, Juan Manuel |
| Spatial Coverage | Mexico |
| Description | Author Affiliation: Echevarría-Zuno S ( Dirección de Prestaciones Médicas, Instituto Mexicano del Seguro Social, Mexico City, Mexico.) |
| Abstract | BACKGROUND: In April, 2009, the first cases of influenza A H1N1 were registered in Mexico and associated with an unexpected number of deaths. We report the timing and spread of H1N1 in cases, and explore protective and risk factors for infection, severe disease, and death. METHODS: We analysed information gathered by the influenza surveillance system from April 28 to July 31, 2009, for patients with influenza-like illness who attended clinics that were part of the Mexican Institute for Social Security network. We calculated odds ratios (ORs) to compare risks of testing positive for H1N1 in those with influenza-like illness at clinic visits, the risk of admission for laboratory-confirmed cases of H1N1, and of death for inpatients according to demographic characteristics, clinical symptoms, seasonal influenza vaccine status, and elapsed time from symptom onset to admission. FINDINGS: By July 31, 63 479 cases of influenza-like illness were reported; 6945 (11%) cases of H1N1 were confirmed, 6407 (92%) were outpatients, 475 (7%) were admitted and survived, and 63 (<1%) died. Those aged 10-39 years were most affected (3922 [56%]). Mortality rates showed a J-shaped curve, with greatest risk in those aged 70 years and older (10.3%). Risk of infection was lowered in those who had been vaccinated for seasonal influenza (OR 0.65 [95% CI 0.55-0.77]). Delayed admission (1.19 [1.11-1.28] per day) and presence of chronic diseases (6.1 [2.37-15.99]) were associated with increased risk of dying. INTERPRETATION: Risk communication and hospital preparedness are key factors to reduce mortality from H1N1 infection. Protective effects of seasonal influenza vaccination for the virus need to be investigated. FUNDING: None. |
| ISSN | 01406736 |
| e-ISSN | 1474547X |
| Journal | The Lancet |
| Issue Number | 9707 |
| Volume Number | 374 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2009-12-19 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Influenza A Virus, H1N1 Subtype Influenza, Human Epidemiology Adolescent Child, Preschool Chronic Disease Infant Infant, Newborn Influenza Vaccines Mortality Prevention & Control Mexico Retrospective Studies Medicine |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine |
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