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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Dunn, Robert C. Armendariz, Kevin P. |
| Description | Author Affiliation: Armendariz KP ( Ralph N. Adams Institute for Bioanalytical Chemistry, University of Kansas, 2030 Becker Drive, Lawrence, Kansas 66047, USA.) |
| Abstract | Single molecule fluorescence measurements are used to probe the effects of GM1 in DPPC monolayers. Langmuir-Blodgett films of GM1 and DPPC were doped with ~10(-8) mol % of the fluorescent lipid probe, BODIPY-PC, and transferred onto glass substrates at 23 mN/m. As shown previously, the individual orientation of each BODIPY-PC probe in the membrane can be measured using defocused polarized total internal reflection fluorescence microscopy, revealing changes in film properties at the molecular level. Here, BODIPY-PC tilt angle histograms are used to characterize the effects of GM1 in DPPC films from 0.05 to 100 mol % GM1. At high GM1 levels (>5 mol % GM1), trends in the single molecule measurements agree with previous bulk measurements showing the turnover from condensing to expanding influence of GM1 at 15-20 mol %, thus validating the single molecule approach. At biologically relevant, low concentrations of GM1 (<5 mol % GM1), where bulk fluorescence measurements are less informative, the single molecule measurements reveal a marked influence of GM1 on film properties. The addition of trace amounts of GM1 to DPPC films leads to an expansion of the film which continues to 0.10 mol % GM1, above which the trend reverses and the condensing effect previously noted is observed. |
| ISSN | 15206106 |
| e-ISSN | 15205207 |
| Journal | The Journal of Physical Chemistry B |
| Issue Number | 26 |
| Volume Number | 117 |
| Language | English |
| Publisher | American Chemical Society (United States) |
| Publisher Date | 2013-07-03 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | 1,2-Dipalmitoylphosphatidylcholine Metabolism Boron Compounds Fluorescent Dyes G(M1) Ganglioside Heterocyclic Compounds, 3-Ring Fluorescence Research Support, N.I.H., Extramural Physical chemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Surfaces, Coatings and Films Materials Chemistry Medicine Physical and Theoretical Chemistry |
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