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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Mewis, Ryan E. Highton, Louise A. R. Duckett, Simon B. Burns, Michael J. Rayner, Peter J. Green, Gary G. R. |
| Description | Author Affiliation: Burns MJ ( Centre for Hyperpolarization in Magnetic Resonance, Department of Chemistry, University of York, York YO10 5NY, United Kingdom.); Rayner PJ ( Centre for Hyperpolarization in Magnetic Resonance, Department of Chemistry, University of York, York YO10 5NY, United Kingdom.); Green GG ( Centre for Hyperpolarization in Magnetic Resonance, Department of Chemistry, University of York, York YO10 5NY, United Kingdom.); Highton LA ( Centre for Hyperpolarization in Magnetic Resonance, Department of Chemistry, University of York, York YO10 5NY, United Kingdom.); Mewis RE ( Centre for Hyperpolarization in Magnetic Resonance, Department of Chemistry, University of York, York YO10 5NY, United Kingdom.); Duckett SB ( Centre for Hyperpolarization in Magnetic Resonance, Department of Chemistry, University of York, York YO10 5NY, United Kingdom.) |
| Abstract | Traditional $^{31}P$ NMR or MRI measurements suffer from low sensitivity relative to $^{1}H$ detection and consequently require longer scan times. We show here that hyperpolarization of $^{31}P$ nuclei through reversible interactions with parahydrogen can deliver substantial signal enhancements in a range of regioisomeric phosphonate esters containing a heteroaromatic motif which were synthesized in order to identify the optimum molecular scaffold for polarization transfer. A 3588-fold $^{31}P$ signal enhancement (2.34% polarization) was returned for a partially deuterated pyridyl substituted phosphonate ester. This hyperpolarization level is sufficient to allow single scan $^{31}P$ MR images of a phantom to be recorded at a 9.4 T observation field in seconds that have signal-to-noise ratios of up to 94.4 when the analyte concentration is 10 mM. In contrast, a 12 h 2048 scan measurement under standard conditions yields a signal-to-noise ratio of just 11.4. $^{31}P-hyperpolarized$ images are also reported from a 7 T preclinical scanner. |
| ISSN | 15206106 |
| e-ISSN | 15205207 |
| Journal | The Journal of Physical Chemistry B |
| Issue Number | 15 |
| Volume Number | 119 |
| Language | English |
| Publisher | American Chemical Society (United States) |
| Publisher Date | 2015-04-16 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Magnetic Resonance Spectroscopy Phosphorus Radioisotopes Chemistry Carbon Radioisotopes Esters Hydrogen Instrumentation Methanol Molecular Structure Phantoms, Imaging Protons Solvents Research Support, Non-U.S. Gov't Physical chemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Surfaces, Coatings and Films Materials Chemistry Medicine Physical and Theoretical Chemistry |
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