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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Guo, Lijun Li, Jiang Sancar, Aziz Ai, Yuejie Zhong, Dongping Tan, Chuang Luo, Yi Wang, Lijuan |
| Description | Author Affiliation: Tan C ( Department of Physics, Department of Chemistry and Biochemistry, and Programs of Biophysics, Chemical Physics, and Biochemistry, The Ohio State University , 191 West Woodruff Avenue, Columbus, Ohio 43210, United States.) |
| Abstract | Photoantenna is essential to energy transduction in photoinduced biological machinery. A photoenzyme, photolyase, has a light-harvesting pigment of methenyltetrahydrofolate (MTHF) that transfers its excitation energy to the catalytic flavin cofactor FADH¯ to enhance DNA-repair efficiency. Here we report our systematic characterization and direct determination of the ultrafast dynamics of resonance energy transfer from excited MTHF to three flavin redox states in E. coli photolyase by capturing the intermediates formed through the energy transfer and thus excluding the electron-transfer quenching pathway. We observed 170 ps for excitation energy transferring to the fully reduced hydroquinone FADH¯, 20 ps to the fully oxidized FAD, and 18 ps to the neutral semiquinone $FADH^{•},$ and the corresponding orientation factors $(κ^{2})$ were determined to be 2.84, 1.53 and 1.26, respectively, perfectly matching with our calculated theoretical values. Thus, under physiological conditions and over the course of evolution, photolyase has adopted the optimized orientation of its photopigment to efficiently convert solar energy for repair of damaged DNA. |
| ISSN | 10895639 |
| e-ISSN | 15205215 |
| Journal | The Journal of Physical Chemistry A |
| Issue Number | 45 |
| Volume Number | 118 |
| Language | English |
| Publisher | American Chemical Society (United States) |
| Publisher Date | 2014-11-13 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Deoxyribodipyrimidine Photo-Lyase Chemistry Energy Transfer Escherichia Coli Proteins Folic Acid Analogs & Derivatives Escherichia Coli Flavin-Adenine Dinucleotide Oxidation-Reduction Riboflavin Spectrum Analysis Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Physical chemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Physical and Theoretical Chemistry |
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