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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Bissell, D. M. Hammaker, L. Schmid, R. |
| Abstract | Sequestration and degradation of red blood cells (RBC) are believed to occur in part in the liver, but the magnitude and cellular localization of this process remain uncertain. This problem was studied in rats by investigating isolated parenchymal and sinusoidal cell populations of the liver. After digesting the perfused liver with pronase, hepatic sinusoidal cells were isolated free of RBC and debris. Of the isolated cells, 90% were phagocytic, as judged by their uptake of colloidal (198)Au or of aggregated albumin-(131)I administered in vivo After administration of spherocytic (heat-treated) RBC, however, only about one quarter of the isolated cells were found to contain phagocytized RBC. This apparently distinct population of RBC-phagocytizing cells is designated as 'erythrophagocytic (EP)' cells. The EP cell population was further characterized functionally by its specific phagocytosis of colloidal carbon and of (99m)technetium-sulfur colloid and histochemically by its peroxidase activity. The role of the EP population in the catabolism of RBC-hemoglobin was studied in isolated hepatic sinusoidal cells by assay of microsomal heme oxygenase (MHO), which is the inducible enzyme system that converts heme to bilirubin. The MHO activity of individual sinusoidal isolates was related directly to their content of EP cells Assay of the MHO activity of the whole spleen and of the total EP cell population of the liver suggested that these two tissues may be of comparable importance in their ability to degrade RBC-hemoglobin. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 1 |
| Volume Number | 54 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 1972-07-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Erythrocytes Liver Cytology Phagocytosis Animals Autoradiography Metabolism Cell Survival Enzymology Gold Colloid, Radioactive Heme Hot Temperature Microsomes, Liver Oxygenases Peroxidases Pronase Rats, Inbred Strains Serum Albumin, Radio-Iodinated Spleen Technetium Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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