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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Sachs, L. Rutishauser, U. |
| Abstract | The cell-to-cell binding induced by concanavalin A (Con A) and the lectins from wheatgerm, soybean, and waxbean has been analyzed by measuring the ability of single cells to bind to lectin-coated cells immobilized on nylon fibers. The cells used were lymphoma, myeloid leukemia, and normal fibroblast cells. With all lectins, cell-to-cell binding was inhibited if both cells were prefixed with glutaraldehyde. However, in most cases cell-to-cell binding was enhanced when only the lectin-coated cell was prefixed. With normal fibroblasts, treatment of either one or both cells with trypsin enhanced the cell-to-cell binding induced by Con A and the wheatgerm lectin. Neuraminidase, which increases the number of receptors for soybean agglutinin, increased cell-to-cell binding only if both cells were treated. Although cell-to- cell binding induced by the lectins from soybean and wheatgerm could be partially reversed by the appropriate competitive saccharide inhibitor, binding induced by Con A could not be reversed. The experiments indicate that cell-to-cell binding induced by a lectin can be prevented by an insufficient density of receptors for the lectin, insufficient receptor mobility, or induced clustering of receptors. These effects can explain the differences in cell-to-cell binding and agglutination observed with different cell types and lectins. They also suggest that cell-to-cell binding induced by different lectins with a variety of cell types is initiated by a mechanism involving the alignment of complementary receptors on the colliding cells for the formation of multiple cell-to-lectin-to-cell bridges. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 2 |
| Volume Number | 65 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 1975-05-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Agglutination Binding Sites, Antibody Lectins Pharmacology Drug Effects Animals Cell Adhesion Cell Line Cells, Cultured Clone Cells Concanavalin A Cricetinae Fibroblasts Glutaral Leukemia, Myeloid Lymphoma Mice Models, Biological Neuraminidase Nylons Plant Lectins Soybeans Triticum Trypsin Vegetables Comparative Study Research Support, U.S. Gov't, P.H.S. Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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