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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Bauduin, H. Vincent, D. Stock, C. Grenier, J. F. |
| Abstract | The microfilaments in the acinar cell of the exocrine pancreas are essentially located in the apical part of the cell: thin microfilaments (50 A), cytochalasin B (CB)-sensitive, form the axis of the microvilli and a network lying beneath the apical membrane; thicker filaments (100 A), at least partly CB-insensitive, form bundles parallel to the plasma cell membrane and the desmosomal links. CB interaction with the acinar cell of the exocrine pancreas involves at least two sites: a membrane site involved in the inhibitory effect of CB on the monosaccharide transport and a less sensitive site at the filamentous level at least partly responsible for the inhibitory effect of CB in the secretion of the exportable enzyme from the pancreatic cell. CB did not alter the energy balance of the acinar cell nor the exchanges of 15-Ca between the extracellular medium and the pancreatic tissue. CB (2 times 10- minus 7 and 2 times 10-minus 6 M) has secretagogue properties whereas CB (2 times 10-minus 5 M) has inhibitory effect on stimulated secretion and secretagogue properties. The mechanism of these secretory effects is not yet explained. The analysis presented in this investigation affords strong evidence for the involvement of the microfilamentous network in the last steps of the secretory cycle in the acinar cell of the exocrine pancreas. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 1 |
| Volume Number | 66 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 1975-07-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Chymotrypsinogen Secretion Cytochalasin B Pharmacology Lipase Pancreas Adenosine Triphosphate Metabolism Animals Calcium Carbachol Carbon Radioisotopes Cerulenin Cytoplasm Ultrastructure Cytoplasmic Granules Deoxyglucose Dose-Response Relationship, Drug Glucose Microscopy, Electron Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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