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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Saure, A. Kahri, A. I. Salmenperä, M. |
| Abstract | Cortical cells of fetal rat adrenals in tissue culture were treated with 5-bromodeoxyuridine (BrdU) during their proliferative phase and during ACTH stimulation when nuclear DNA synthesis has almost ceased. Pretreatment with 0.5 mug/ml/day of BrdU inhibited the ACTH-induced differentiation of cortical cells as well as the secretion of corticosterone and 18-OH-deoxycorticosterone (18-OHDOC). When nuclear DNA synthesis was suppressed and mitochondrial DNA synthesis was stimulated by ACTH BrdU addition (30 mug/ml/day) permitted normal untrastructural differentiation of cortical cells, except that the development of mitochondrial inner membranes was inhibited. Simultaneously mitochondrial inner membranes was inhibited. Simultaneously mitochondrial 11beta- and 18-hydroxylations were strongly inhibited while cytoplasmic 21-hydroxylation was not affected. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 3 |
| Volume Number | 71 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 1976-12-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Adrenal Cortex Ultrastructure Adrenal Glands Adrenocorticotropic Hormone Pharmacology Bromodeoxyuridine Mitochondria Embryology Metabolism Animals Cell Differentiation Drug Effects Cells, Cultured Corticosterone Secretion DNA Biosynthesis Desoxycorticosterone Morphogenesis Progesterone Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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