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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Emr, S. D. Silhavy, T. J. |
| Abstract | We are studying the mechanism by which the LamB protein is exported to the outer membrane of Escherichia coli. Using two selection procedures based on gene fusions, we have identified a number of mutations that cause alterations in the LamB signal sequence. Characterization of the mutant strains revealed that although many such mutations block LamB export to greater than 95%, others have essentially no effect. These results allow an analysis of the functions performed by the various molecular components of the signal sequence. Our results suggest that a critical subset of four amino acids is contained within the central hydrophobic core of the LamB signal sequence. If this core can assume an alpha-helical conformation, these four amino acids comprise a recognition site that interacts with a component of the cellular export machinery. Since mechanisms of protein localization appear to have been conserved during evolution, the principles established by these results should be applicable to similar studies in eukaryotic cells. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 3 |
| Volume Number | 95 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 1982-12-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Escherichia Coli Genetics Genes, Bacterial Peptides Receptors, Virus Metabolism Bacterial Outer Membrane Proteins Biological Transport Cell Membrane DNA, Recombinant Mutation Physiology Porins Protein Conformation Protein Sorting Signals Research Support, U.S. Gov't, P.H.S. Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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