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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Orci, L. Perrelet, A. Amherdt, M. Ravazzola, M. Vassalli, J. D. Halban, P. |
| Abstract | The secretion of insulin by the pancreatic B-cell involves a passage of the newly synthetized (pro)insulin polypeptides across the Golgi apparatus, at the trans pole of which secretory proteins are released as a population of secretory granules characterized by a clathrinlike coat on segments of their limiting membrane. When the conversion of radiolabeled proinsulin to insulin was inhibited by replacing arginine and lysine with the aminoacid analogs, canavanine and thialysine, the nonconverted radioactive material remained associated with Golgi- derived, coated secretory granules. The coat was characterized as clathrin-containing by immunocytochemistry. Under analog treatment, the noncoated, storage secretory granules did not become markedly labeled during the pulse-chase experiment. These data are compatible with the hypothesis that in normal conditions, the maturation of the coated compartment into noncoated granules is linked to the effective conversion of the prohormone. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 6 |
| Volume Number | 99 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 1984-12-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Clathrin Physiology Cysteine Analogs & Derivatives Golgi Apparatus Metabolism Intracellular Membranes Islets Of Langerhans Proinsulin Animals Autoradiography Ultrastructure Kinetics Microscopy, Electron Tritium Research Support, Non-U.S. Gov't Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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