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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Harlan, J. M. Heimark, R. L. Chen, C. S. Thiagarajan, P. Schwartz, S. M. |
| Description | Author Affiliation: Chen CS ( Department of Medicine, University of Washington, Seattle 98195.) |
| Abstract | On platelets the membrane glycoprotein IIb/IIIa complex (GPIIb/IIIa) functions in adhesive interactions with fibrinogen, von Willebrand factor, and fibronectin. However, the function of GPIIb/IIIa-like proteins on endothelial cells, as well as the ligand(s) the complex binds, is unknown. Using a highly specific polyclonal antibody we have explored the function of GPIIb/IIIa-like proteins on human umbilical vein endothelial cells (HUVE). Analysis by immunoblotting shows that this antiserum recognizes the endothelial GPIIIa-like protein of the complex. The IgG fraction of the polyclonal antiserum and its Fab' fragments detach confluent and subconfluent HUVE from extracellular substrata. The effect of the anti-GPIIb/IIIa IgG is not toxic as the detached cells maintain their viability after trypsinization and replating. Anti-GPIIb/IIIa IgG does not inhibit HUVE binding to extracellular matrix or purified fibronectin in an attachment assay despite the presence of intact GPIIb/IIIa on HUVE detached from substrate by various methods. Apparently, the GPIIb/IIIa-like protein on HUVE is important in normal HUVE adhesion to the extracellular matrix, but it is not required in the initial attachment of HUVE to extracellular matrix. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 4 |
| Volume Number | 105 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 1987-10-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Cell Adhesion Endothelium, Vascular Metabolism Extracellular Matrix Membrane Proteins Platelet Membrane Glycoproteins Electrophoresis, Polyacrylamide Gel Immunologic Techniques Immunosorbent Techniques Molecular Weight Oligopeptides Chemical Synthesis Immunology Receptors, Cell Surface Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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