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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Leinwand, L. A. Feghali, R. |
| Description | Author Affiliation: Feghali R ( Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461.) |
| Abstract | We have isolated a human cDNA which corresponds to a developmentally regulated sarcomeric myosin heavy chain. RNA hybridization and DNA sequence analysis indicate that this cDNA, called SMHCP, encodes a perinatal myosin heavy chain isoform. The nucleotide and deduced amino acid sequences of the 3.4-kb cDNA insert show strong homology with other sarcomeric myosin heavy chains. The strongest homology is to a previously described 970-bp cDNA encoding a rat perinatal isoform (Periasamy, M., D. F. Wieczorek, and B. Nadal-Ginard. 1984. J. Biol. Chem. 259:13573-13578). The homology between the analogous human and rat perinatal myosin heavy chain cDNAs is maintained through the highly isoform-specific final 20 carboxyl-terminal amino acids, as well as the 3' untranslated region. Ribonuclease protection studies show that the mRNA encoding this isoform is expressed at high levels in 21-wk fetal skeletal tissue and not in fetal cardiac muscle. In contrast to the rat perinatal isoform, which was not found to be expressed in adult hind- leg tissue, the gene encoding SMHCP continues to be expressed in adult human skeletal tissue, but at lower levels relative to fetal skeletal tissue. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 5 |
| Volume Number | 108 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 1989-05-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Genes Muscle Development Myosins Genetics Peptide Fragments Aging Amino Acid Sequence Animals DNA Isolation & Purification Embryo, Mammalian Heart Embryology Growth & Development Major Histocompatibility Complex Molecular Sequence Data Muscles Myosin Subfragments Nucleic Acid Hybridization RNA, Messenger Sequence Homology, Nucleic Acid Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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