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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Blasi, F. Danø, K. Eriksen, J. Kristensen, P. |
| Description | Author Affiliation: Kristensen P ( Finsen Laboratory, Rigshospitalet, Copenhagen, Denmark.) |
| Abstract | Two mouse urokinase-type plasminogen activator receptor (muPAR) cDNAs were isolated: muPAR1 is homologous to the human urokinase-type plasminogen activator receptor while muPAR2 codes for a 199 residue protein sharing the first 133 residues with muPAR1. Mouse genomic DNA sequencing indicates that the two different mRNAs arise by alternative splicing. In situ hybridization showed differential expression of the two mRNAs in mouse gastric mucosa. muPAR1 mRNA is located in luminal epithelial cells situated close to urokinase-type plasminogen activator- producing connective tissue cells of the lamina propria, pointing to plasmin generation controlled by the cooperation of different cells that may play a role in the release of gastric epithelial cells. muPAR2 mRNA is expressed in the basal epithelial cells, and the deduced protein sequence includes the receptor ligand binding domain, but omits the region involved in glycolipid-mediated membrane anchoring, suggesting that muPAR2 may code for a secreted uPA binding protein. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 6 |
| Volume Number | 115 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 1991-12-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Gastric Mucosa Metabolism RNA Splicing Receptors, Cell Surface Genetics Urokinase-Type Plasminogen Activator Amino Acid Sequence Animals DNA Isolation & Purification Mice Molecular Sequence Data Nucleic Acid Hybridization Protein Biosynthesis RNA, Messenger Receptors, Urokinase Plasminogen Activator Sequence Alignment Sequence Homology, Nucleic Acid Research Support, Non-U.S. Gov't Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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