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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Novick, P. Govindan, B. Bowser, R. Müller, H. |
| Description | Author Affiliation: Bowser R ( Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06510.) |
| Abstract | The SEC8 and SEC15 genes are essential for exocytosis in the yeast Saccharomyces cerevisiae and exhibit strong genetic interactions with SEC4, a gene of the ras superfamily. The SEC8 gene encodes a hydrophilic protein of 122 kD, while the temperature-sensitive sec8-9 allele encodes a protein prematurely truncated at 82 kD by an opal stop codon. The Sec8p sequence contains a 202 amino acid region that is 25% identical to the leucine rich domain of yeast adenylate cyclase that has been implicated in ras responsiveness. Fractionation, stability, and cross-linking studies indicate that Sec8p is a component of a 19.5S particle that also contains Sec15p. This particle is found both in the cytosol and peripherally associated with the plasma membrane, but it is not associated with secretory vesicles. Gel filtration studies suggest that a portion of Sec4p is in association with the Sec8p/Sec15p particle. We propose that this particle may function as a downstream effector of Sec4p, serving to direct the fusion of secretory vesicles with the plasma membrane. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 5 |
| Volume Number | 118 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 1992-09-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Carrier Proteins Cell Membrane Chemistry Exocytosis Fungal Proteins GTP-Binding Proteins Saccharomyces Cerevisiae Proteins Saccharomyces Cerevisiae Rab GTP-Binding Proteins Amino Acid Sequence Cloning, Molecular Genetics Metabolism Secretion Genes, Fungal Molecular Sequence Data Molecular Weight Mutation Solubility Vesicular Transport Proteins Research Support, U.S. Gov't, P.H.S. Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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