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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Bennett, R. I. Hogg, N. Landis, R. C. |
| Description | Author Affiliation: Landis RC ( Macrophage Laboratory, Imperial Cancer Research Fund, London, United Kingdom.) |
| Abstract | A panel of 21 alpha-subunit (CD11a) and 10 beta-subunit (CD18) anti-LFA- 1 mAbs was screened for ability to activate LFA-1. A single anti-CD11a mAb, MEM-83, was identified which was able to directly induce the binding of T cells to purified ICAM-1 immobilized on plastic. This ICAM- 1 binding could be achieved by monovalent Fab fragments of mAb MEM-83 at concentrations equivalent to whole antibody, was associated with appearance of the "activation reporter" epitope detected by mAb 24, and was completely inhibited by anti-ICAM-1 and LFA-1 blocking mAbs. The epitope recognized by mAb MEM-83 was distinct from that recognized by mAb NKI-L16, an anti-CD11a mAb previously reported to induce LFA-1 activation, in that it was constitutively present on freshly isolated peripheral blood mononuclear cells and was not divalent cation dependent for expression. The ICAM-1 binding activity induced by mAb MEM-83 was, however, dependent on the presence of Mg2+ divalent cations. Using an in vitro-translated CD11a cDNA deletion series, we have mapped the MEM-83 activation epitope to the "I" domain of the LFA- 1 alpha subunit. These studies have therefore identified a novel LFA-1 activation epitope mapping to the I domain of LFA-1, thereby implicating this domain in the regulation of LFA-1 binding to ICAM-1. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 6 |
| Volume Number | 120 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 1993-03-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Antibodies, Monoclonal Antigens, CD Immunology Cell Adhesion Molecules Metabolism Epitopes Lymphocyte Activation Lymphocyte Function-Associated Antigen-1 T-Lymphocytes Antigen-Antibody Complex Genetics Antigens, CD11 Antigens, CD18 Cell Aggregation Cloning, Molecular Immunoglobulin Fab Fragments Intercellular Adhesion Molecule-1 Macromolecular Substances Polymerase Chain Reaction Protein Biosynthesis Recombinant Proteins Sequence Deletion Transcription, Genetic Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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