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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Blobel, G. Rout, M. P. Wozniak, R. W. |
| Description | Author Affiliation: Wozniak RW ( Laboratory of Cell Biology, Howard Hughes Medical Institute, Rockefeller University, New York 10021.) |
| Abstract | We have identified a concanavalin A-reactive glycoprotein of 150 kD that coenriches with isolated yeast nuclear pore complexes. Molecular cloning and sequencing of this protein revealed a single canonical transmembrane segment. Epitope tagging and localization by both immunofluorescence and immunoelectron microscopy confirmed that it is a pore membrane protein. The protein was termed POM152 (for pore membrane protein of 152 kD) on the basis of its location and cDNA-deduced molecular mass. POM152 is likely to be a type II membrane protein with its NH2-terminal region (175 residues) and its COOH-terminal region (1,142 residues) positioned on the pore side and cisternal side of the pore membrane, respectively. The proposed cisternally exposed domain contains eight repetitive motifs of approximately 24 residues. Surprisingly, POM152 deletion mutants were viable and their growth rate was indistinguishable from that of wild-type cells at temperatures between 17 and 37 degrees C. However, overproduction of POM152 inhibited cell growth. When expressed in mouse 3T3 cells, POM152 was found to be localized to the pore membrane, suggesting a conserved sorting pathway between yeast and mammals. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 1 |
| Volume Number | 125 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 1994-04-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Fungal Proteins Metabolism Membrane Glycoproteins Nuclear Envelope Chemistry Nuclear Proteins Saccharomyces Cerevisiae Proteins 3T3 Cells Amino Acid Sequence Animals Genetics Genes, Fungal Mice Molecular Sequence Data Mutagenesis, Insertional Nuclear Pore Repetitive Sequences, Nucleic Acid Saccharomyces Cerevisiae Sequence Alignment Sequence Homology, Amino Acid Comparative Study Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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