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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Schekman, R. Kuehn, M. J. Ljungdahl, P. O. |
| Description | Author Affiliation: Kuehn MJ ( Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley 94720, USA.) |
| Abstract | In S. cerevisiae lacking SHR3, amino acid permeases specifically accumulate in membranes of the endoplasmic reticulum (ER) and fail to be transported to the plasma membrane. We examined the requirements of transport of the permeases from the ER to the Golgi in vitro. Addition of soluble COPII components (Sec23/24p, Sec13/31p, and Sar1p) to yeast membrane preparations generated vesicles containing the general amino acid permease. Gap1p, and the histidine permease, Hip1p. Shr3p was required for the packaging of Gap1p and Hip1p but was not itself incorporated into transport vesicles. In contrast, the packaging of the plasma membrane ATPase, Pma1p, and the soluble yeast pheromone precursor, glycosylated pro alpha factor, was independent of Shr3p. In addition, we show that integral membrane and soluble cargo colocalize in transport vesicles, indicating that different types of cargo are not segregated at an early step in secretion. Our data suggest that specific ancillary proteins in the ER membrane recruit subsets of integral membrane protein cargo into COPII transport vesicles. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 3 |
| Volume Number | 135 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 1996-11-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | ATP-Binding Cassette Transporters Amino Acid Transport Systems, Basic Bacterial Proteins Endoplasmic Reticulum Metabolism Membrane Proteins Physiology Membrane Transport Proteins Monomeric GTP-Binding Proteins Saccharomyces Cerevisiae Proteins Amino Acid Transport Systems Biological Transport, Active COP-Coated Vesicles Fungal Proteins Pharmacology GTP-Binding Proteins GTPase-Activating Proteins Golgi Apparatus Intracellular Membranes Microsomes Nuclear Pore Complex Proteins Peptides Protein Precursors Proton-Translocating ATPases Saccharomyces Cerevisiae Enzymology Spheroplasts Vesicular Transport Proteins Research Support, Non-U.S. Gov't Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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