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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Pereira, A. J. Doxsey, S. J. Stewart, R. J. Dalby, B. Goldstein, L. S. |
| Description | Author Affiliation: Pereira AJ ( Program in Molecular Medicine, University of Massachusetts Medical Center, Worcester 01605, USA.) |
| Abstract | The kinesin superfamily is a large group of proteins (kinesin-like proteins [KLPs]) that share sequence similarity with the microtubule (MT) motor kinesin. Several members of this superfamily have been implicated in various stages of mitosis and meiosis. Here we report our studies on KLP67A of Drosophila. DNA sequence analysis of KLP67A predicts an MT motor protein with an amino-terminal motor domain. To prove this directly, KLP67A expressed in Escherichia coli was shown in an in vitro motility assay to move MTs in the plus direction. We also report expression analyses at both the mRNA and protein level, which implicate KLP67A in the localization of mitochondria in undifferentiated cell types. In situ hybridization studies of the KLP67A mRNA during embryogenesis and larval central nervous system development indicate a proliferation-specific expression pattern. Furthermore, when affinity-purified anti-KLP67A antisera are used to stain blastoderm embryos, mitochondria in the region of the spindle asters are labeled. These data suggest that KLP67A is a mitotic motor of Drosophila that may have the unique role of positioning mitochondria near the spindle. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 5 |
| Volume Number | 136 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 1997-03-10 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Drosophila Proteins Drosophila Genetics Microtubule-Associated Proteins Microtubules Metabolism Mitochondria Chemistry Mitosis Physiology Amino Acid Sequence Animals CHO Cells Cricetinae DNA, Complementary Embryology Escherichia Coli Gene Expression Regulation, Developmental Isolation & Purification Molecular Sequence Data RNA, Messenger Recombinant Fusion Proteins Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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