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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Jungnickel, B. Mothes, W. Rapoport, T. A. Brunner, J. |
| Description | Author Affiliation: Mothes W ( Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA.) |
| Abstract | We have investigated the role of membrane proteins and lipids during early phases of the cotranslational insertion of secretory proteins into the translocation channel of the endoplasmic reticulum (ER) membrane. We demonstrate that all steps, including the one during which signal sequence recognition occurs, can be reproduced with purified translocation components in detergent solution, in the absence of bulk lipids or a bilayer. Photocross-linking experiments with native membranes show that upon complete insertion into the channel signal sequences are both precisely positioned with respect to the protein components of the channel and contact lipids. Together, these results indicate that signal sequences are bound to a specific binding site at the interface between the channel and the surrounding lipids, and are recognized ultimately by protein–protein interactions. Our data also suggest that at least some signal sequences reach the binding site by transfer through the interior of the channel. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 2 |
| Volume Number | 142 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 1998-07-27 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Endoplasmic Reticulum Metabolism Membrane Proteins Saccharomyces Cerevisiae Proteins Signal Recognition Particle Animals Binding Sites Biological Transport, Active Cross-Linking Reagents Detergents Fungal Proteins Genetics In Vitro Techniques Intracellular Membranes Membrane Lipids Prolactin Protein Biosynthesis Protein Precursors Ribosomes Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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